Abstract：Objective To compare the efficacy and safety of Cefuroxime and Amoxicillin in the eradication treatment of Helicobacter pylori (Hp). Methods A total of 160 patients diagnosed with Hp infection in the Outpatient Department of Liuzhou People’s Hospital of Guangxi Zhuang Autonomous Region from December 2017 to July 2020 were selected as the research subjects. Among them, 80 were initially treated patients who had not received previous Hp eradication treatment, and 80 patients were treated with bismuth drug quadruple regimen for 14 days to eradicate Hp after treatment failure. According to random number table method they were divided into treated first Cefuroxime, first Amoxicillin group and re-treat Cefuroxime and re-treat Amoxicillin group, with 40 cases in each group. Based on Rabeprazole, Furazolidone, and Colloidal bismuth pectin, combination respectively Cefuroxime or Amoxicillin Hp eradication therapy, treatment discontinuation ended at least four weeks after the review of Hp. The eradication rate of Hp and the incidence of adverse reactions in each group were compared. Results There was no significant difference in the eradication rate of Hp between first Cefuroxime group and first Amoxicillin group (P ＞ 0.05). There was no significant difference in the eradication rate of Hp between the re-treat Cefuroxime group and the re-treat Amoxicillin group (P ＞ 0.05). There was no statistical significance in the total incidence of adverse reactions among all groups (P ＞ 0.05). Conclusion There is no significant difference in the eradication rate of Hp between the quadruple therapy containing Cefuroxime and Amoxicillin, and similar eradication rates are obtained for both initial treatment and retreatment. For some patients who are not suitable for Penicillin, Cefuroxime may be a good alternative to Amoxicillin.
刘敏芝 李运泽 韦天灵 蔡怀阳 秦敏. 头孢呋辛和阿莫西林对幽门螺杆菌根除治疗的效果比较[J]. 中国医药导报, 2021, 18(28): 113-116.
LIU Minzhi LI Yunze WEI Tianling CAI Huaiyang QIN Min. Comparison of efficacy of Cefuroxime and Amoxicillin in the eradication treatment of Helicobacter pylori. 中国医药导报, 2021, 18(28): 113-116.
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