Effect of Shenqi Xiaozhi Recipe on appetite of ICR obese mice
LIU Yingke1 REN Xinxin1 LI Tianxin2 YANG Ye1 WANG Qiuli1 ZHANG Chen1
1.Department of Pediatric, Beijing Hepingli Hospital, Beijing 100013, China;
2.the First Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100029, China
Abstract：Objective To study the effect of Shenqi Xiaozhi Recipe on the appetite of ICR obese mice. Methods A total of 50 male SPF grade ICR mice (eight weeks old) were took, all weighing (250±10) g, and random number table method was used to select eight mice as normal group. The normal group was given normal feed, and the others were given high-fat feeding. After 12 weeks of administration, 10% of the body weight greater than the normal group indicated that the model was successful. In order of numbering, eight animals were selected as the model group and eight as the drug group. The drug group was given Shenqi Xiaozhi Recipe by gavage intervention, and the other two groups were given distilled water gavage intervention, the administration volume was 0.2 ml/10 g. All groups were given intragastric administration for 12 weeks, once a day. At 6 and 12 weeks of administration, the body fat, weight and food intake of three groups were measured. Results Compared with the model group, the food intake of the drug group at 6 and 12 weeks of administration decreased significantly, and the differences were statistically significant (P < 0.05). Compared with the normal group, the net weight gain of the model group increased significantly after 12 weeks of administration, and the difference was statistically significant (P < 0.05); compared with the model group, the net weight gain of the drug group at 6 and 12 weeks of administration were significantly reduced, and the differences were statistically significant (P < 0.05). There was a statistically significant difference in the net weight gain between the model group and the administration group after 12 weeks of administration and 6 weeks of administration (P ＜ 0.05). Compared with the normal group, the body fat ratio of the model group increased at 6 and 12 weeks after administration, and the differences were statistically significant (P < 0.05). After 12 weeks of administration, the body fat ratio of the model group was higher than that of six weeks of administration, and the difference was statistically significant (P <0.05). Conclusion Shenqi Xiaozhi Recipe can reduce the appetite of ICR obese mice and improve body weight to a certain extent.
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