Meta-analysis of the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion
XIE Jiahao1 GUO Haiwei1 WANG Yufeng2 CHEN Bolai2 FU Miaoling3 YANG Qingqi4
1.The Second Clinical Medical College, Guangzhou University of Chinese Medicine, Guangdong Province, Guangzhou 510000, China;
2.the First Department of Orthopedics, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Province, Guangzhou 510000, China; 3.Department of Otolaryngology, Meizhou Hospital of Traditional Chinese Medicine, Guangdong Province, Meizhou 514000, China;
4.the Second Clinical Medical College, Guangzhou Medical University, Guangdong Province, Guangzhou 510000, China
Abstract：Objective To systematically evaluate the efficacy and safety of intravenous Tranexamic Acid in short-segment posterior lumbar interbody fusion. Methods Randomized controlled trial from PubMed, Embase, Medline, Cochrane Library, CNKI, CBM, VIP, Wanfang and other self-built databases up to December 2020 were searched using the keywords “trantranic acid” and “lumbar fusion”. The experimental group was intravenous Tranexamic Acid, and the control group was intravenous normal saline. Total blood loss, intraoperative blood loss, postoperative drainage, blood transfusion rate and incidence of deep venous thrombosis events were compared between the two groups. Meta-analysis was performed using RevMan 5.3 software. Results A total of six literatures were included, including 557 patients. Meta-analysis results showed that total blood loss (MD = -280.88, 95%CI: -309.18, -252.59, P ＜ 0.000 01), intraoperative blood loss (MD = -73.34, 95%CI: -128.52, -18.15, P = 0.009), postoperative drainage volume (MD = -150.29, 95%CI: -211.48, -89.10, P ＜ 0.000 01), transfusion rate (OR = 0.32, 95%CI: 0.19, 0.52, P ＜ 0.000 01) in the experimental group were lower than the control group. There was no significant difference in the incidence of deep vein thrombosis events between the two groups (P ＞ 0.05). Conclusion Intravenous Tranexamic Acid is effective and safe in short-segment posterior lumbar interbody fusion, but it needs more high-quality randomized controlled trial to confirm.
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