Abstract:Objective To explore the application effect of preventive nursing intervention with neonatal respiratory distress syndrome (NRDS). Methods A total of 113 children with NRDS admitted to Suzhou Hospital Affiliated to Anhui Medical University from July 2017 to June 2020 were selected, and they were divided into an observation group of 57 cases and a control group of 56 cases according to the random number table method. The control group was given routine treatment and nursing intervention for children with NRDS, and the observation group was combined with preventive nursing intervention. The use time of non-invasive ventilator, hospitalization time and hospitalization expenses, oxygenation function before and a week after treatment, and complications during hospitalization were compared between the two groups. Results The non-invasive ventilator use time, hospitalization time, and hospitalization expenses in the observation group were lower than those in the control group, and the differences were statistically significant (P < 0.05). After a week of treatment, the pH and pulse oxyqen saturatron (SpO2) of the two groups were higher than those of the same group before treatment, while partial pressure of carbon dioxide (PaCO2) was lower than that of the same group before treatment, and the differences were statistically significant (P < 0.05). The pH and SpO2 in the observation group were higher than those of the control group, while PaCO2 was lower than that of the control group, and the differences were statistically significant (P < 0.05). The incidence of complications in the observation group was lower than that in the control group, and the difference was statistically significant (P < 0.05). There was no statistically significant difference in the mortality between the two groups (P > 0.05). Conclusion Preventive nursing intervention can help shorten the use time of non-invasive ventilator and hospital stay, improve lung oxygenation function, and reduce the occurrence of complications.