Abstract：Objective To study the medication rule of traditional Chinese medicine in the treatment of gastroesophageal reflux disease with syndrome of disharmony between liver and stomach, and explore the ideas and theoretical basis of the application of high-frequency core prescription. Methods The clinical journal literatures collected from CNKI, Wanfang, VIP and CBM from January 2010 to December 2020 were taken as data source. “Traditional Chinese medicine inheritance computer system v3.0” was used for data mining, and association analysis and cluster analysis were conducted on the included prescriptions of Chinese medicine, so as to explore high-frequency drugs and usage rules of gastroesophageal reflux disease with syndrome of disharmony between liver and stomach. Results Among the 108 traditional Chinese medicine prescriptions finally included, most of the medicinal characters were “cold” and “warm”, meanwhile, the bitter and pungent were main medical taste. The frequently channel tropism of drugs was spleen, lung, stomach, liver. The function of the medicine was mainly regulating qi-flowing and tonifying, the most frequently used drug was Radix Bupleuri, Radix Paeoniae Alba, and Rhizoma Pinelliae. The high-frequency drug combinations were mainly Radix Glycyrrhizae-Radix Bupleuri, Radix Paeoniae Alba-Pericarpium Citri Reticulatae-Radix Bupleuri, Radix Glycyrrhizae-Rhizoma Cyperi-Radix Bupleuri, 20 core Chinese herbs and 3 groups of new drug-formulations were explored. Conclusion Facing with gastroesophageal reflux disease with syndrome of disharmony between liver and stomach, modern traditional Chinese medicine mostly uses “dispersing stagnated liver qi for regulating stomach, nourishing spleen and stomach” as the main therapeutic ideas, balancing cold and heat, and taking into account both deficiency and excess, so as to achieve the therapeutic effect of “balancing liver-qi and regulating stomach-qi”.
徐景新 陈宏慈. 中医药治疗肝胃不和型胃食管反流病的用药规律研究[J]. 中国医药导报, 2021, 18(26): 152-156.
XU Jingxin CHEN Hongci. Study on the rule of traditional Chinese medicine in treating gastroesophageal reflux disease with syndrome of disharmony between liver and stomach. 中国医药导报, 2021, 18(26): 152-156.
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