止痛化癥胶囊联合注射用头孢他啶治疗慢性盆腔炎的效果

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摘要目的观察止痛化癥胶囊联合注射用头孢他啶治疗慢性盆腔炎的效果。方法选取2019年2月至2020年10月济南市第四人民医院就诊的慢性盆腔炎患者100例，按照随机数字表法分为对照组和观察组，每组50例。对照组患者静脉滴注注射用头孢他啶，观察组在对照组的基础上联合止痛化癥胶囊治疗，两组均治疗14 d。比较两组临床疗效、疼痛情况、盆腔炎性包块直径、超敏C反应蛋白（hs-CRP）、人转化生长因子受体β1（TGF-β1）、丙二醛（MDA）、超氧化物歧化酶（SOD）以及不良反应发生率。结果观察组的临床总有效率高于对照组（P < 0.05）。治疗14 d后，两组hs-CRP、MDA水平低与治疗前，且观察组低于对照组（P < 0.05）；TGF-β1、SOD水平高于治疗前，且观察组高于对照组（P < 0.05）。治疗14 d后，两组视觉模拟评分法评分低于治疗前，且观察组低于对照组（P < 0.05）；两组盆腔炎性包块直径小于治疗前，且观察组小于对照组（P < 0.05）。两组不良反应总发生率比较，差异无统计学意义（P > 0.05）。结论止痛化癥胶囊联合注射用头孢他啶治疗慢性盆腔炎，可有效减轻氧化应激，降低炎症因子水平，改善临床症状，安全可靠。

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	董兆琴1 张娟1 张桂莲2

关键词 ：止痛化癥胶囊, 注射用头孢他啶, 慢性盆腔炎, 疗效

Abstract：Objective To observe the efficacy of Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease. Methods A total of 100 patients with chronic pelvic inflammatory disease from Jinan Fourth People’s Hospital from February 2019 to October 2020 were selected. According to the random number table method, they were divided into control group and observation group, with 50 cases in each group. Control group received intravenous infusion of Ceftazidime for Injection, observation group was treated with Zhitong Huazheng Capsules on the basis of control group, both groups were treated for 14 days. The efficacy, pain, pelvic inflammatory mass diameter, high-sensitivity C-reactive protein (hs-CRP), human transforming growth factor receptor β1 (TGF-β1), malondialdehyde (MDA), superoxide dismutase (SOD), and the incidence of adverse reactions were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). After 14 days of treatment, the levels of hs-CRP and MDA in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05); the levels of TGF-β1 and SOD in two groups were higher than those before treatment, and observation group were higher than control group (P < 0.05). After 14 days of treatment, visual analogue scale score in two groups were lower than those before treatment, and observation group was lower than control group (P < 0.05); the pelvic inflammatory mass diameter in two groups were smaller than those before treatment, and observation group was smaller than control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between two groups (P > 0.05). Conclusion Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease can effectively reduce oxidative stress, reduce the level of inflammatory factors, improve clinical symptoms, it is safe and reliable.

Key words： Zhitong Huazheng Capsules Ceftazidime for Injection Chronic pelvic inflammatory disease Efficacy

基金资助:山东省医药卫生科技项目（2017WS1033）。

通讯作者: 张桂莲（1972.12-），女，硕士，主任医师；研究方向：宫颈病变、盆腔炎症、围产期保健。

作者简介: 董兆琴（1972.9-），女，副主任药师；研究方向：临床药学。

引用本文:

董兆琴1 张娟1 张桂莲2. 止痛化癥胶囊联合注射用头孢他啶治疗慢性盆腔炎的效果[J]. 中国医药导报, 2021, 18(26): 85-89.
DONG Zhaoqin1 ZHANG Juan1 ZHANG Guilian2. Efficacy of Zhitong Huazheng Capsules combined with Ceftazidime for Injection in the treatment of chronic pelvic inflammatory disease. 中国医药导报, 2021, 18(26): 85-89.

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