Analysis of related factors of postconcussional syndrome after mild traumatic brain injury
HE Jianxun1 MENG Qinglong1 DUAN Guanghui1 GU Shuli1 MO Yanhong1 HE Ruifang2 WEI Hongtao1
1.Department of Neurology, the Affiliated Hospital of Northwest University for Nationalities, Gansu Province, Lanzhou 730000, China;
2.Department of Psychosomatic Diseases, the Affiliated Hospital of Northwest University for Nationalities, Gansu Province, Lanzhou 730000, China
Abstract:Objective To analyze the related factors of postconcussional syndrome after mild craniocerebral injury, in order to provide clinical basis for the prevention and treatment of postconcussion syndrome. Methods Clinical data of 48 patients with postconcussional syndrome after mild head injury (case group) and 30 asymptomatic patients (control group) after mild head injury for three months were collected from the Affiliated Hospital of Northwest University for Nationalities from August 2016 to June 2019. Univariate analysis and logistic regression analysis were used to screen the influencing factors of postconcussion syndrome after mild head injury. Results In the case group, the proportion of occupational instability, the proportion of injury caused by violence, the proportion of life stress, the proportion of patients with physical disease before injury, and the proportion of no compensation or litigation after injury were all higher than those in the control group, and the differences were statistically significant (P < 0.05). Multivariate logistic regression analysis showed that occupational stability, other causes of injury, and compensation or litigation were protective factors of postconcussion syndrome after mild head injury (OR < 1, P < 0.05). Conclusion The cause of injury, compensation or litigation, and occupation may be the important influencing factors of postconcussion syndrome after mild brain injury.
[1] Marin JR,Weaver MD,Yealy DM,et al. Trends in visits for traumatic brain injury to emergency departments in the United States [J]. JAMA,2014,311(18):1917-1919.
[2] Gardner RC,Yaffe K. Epidemiology of mild traumatic brainin jury and neurode generative disease [J]. Mol Cell Neurosci 2015,66(Pt B):75-80.
[3] Steven R. Invited Commentary on “Centers for Disease Control and Prevention Report to Congress:Traumatic Brain Injury in the United States:Epidemiology and Rehabilitation”[J]. Arch Phys Med Rehabil,2015,96(10):1753-1755.
[4] McCrory P,Meeuwisse WH,Aubry M,et al. Consensus statement on concussion in sport:the 4th International Conference on Concussion in Sport held in Zurich,November 2012 [J]. Br J Sports Med,2013,16(3):178-189.
[5] McMahon P,Hricik A,Yue JK,et al. Symptomatology and functional outcome in mild traumatic brain injury:results from the prospective TRACK-TBI study [J]. J Neurotrauma,2014,31(1):26-33.
[6] Giza CC,Hovda DA. The new neurometabolic cascade of concussion [J]. Neurosurgery,2014,75(Suppl 4):S24-S33.
[7] Korley FK,Kelen GD,Jones CM,et al. Emergency departmentevaluation of traumatic brain injury in the United States,2009-2010 [J]. J Head Trauma Rehabil,2016,31(6):379-387.
[8] McCrory P,Meeuwisse W,Dvorak J,et al. Consensus statement on concussion in sport-the 5(th)internationalconference on concussion in sport held in Berlin,October 2016 [J]. Br J Sports Med,2017,51(11):838-847.
[9] Cassidy JD,Cancelliere C,Carroll LJ,et al. Systematic review of self-reported prognosis in adults after mild traumatic brain injury:results of the International Collaboration on Mild Traumatic Brain Injury Prognosis [J]. Arch Phys Med Rehabil,2014,95(suppl):S132-S151.
[10] Leddy JJ,Baker JG,Merchant A,et al. Brain or strain?Symptoms alone do not distinguish physiologic concussion from cervical/vestibular injury [J]. Clin J Sport Med,2015,25(3):237-242.
[11] Tan CO,Meehan WP 3rd,Iverson GL,et al. Cerebrovascular regulation,exercise,and mild traumatic brain injury [J]. Neurology,2014,83(18):1665-1672.
[12] Meterko M,Baker E,Stolzmann KL,et al. Psychometric assessment of the Neurobehavioral Symptom Inventory-22:the structure of persistent postconcussive symptoms following deployment-related mild traumatic brain injury among veterans [J]. J Head Trauma Rehabil,2012,27(1):55-62.
[13] Potter S,Leigh E,Wade D,et al. The Rivermead Post Concussion Symptoms Questionnaire:aconfirmatory factor analysis [J]. J Neurol,2006,253(12):1603-1614.
[14] Kontos AP,Elbin RJ,Schatz P,et al. A revised factor structure for the Post-Concussion SymptomScale:baseline and postconcussion factors [J]. Am J Sports Med,2012,40(10):2375-2384.
[15] Müssigbrodt H,Dilling H,Dittmann V,et al. Mental and behavioural disorders due to use of psychoactive substances(F1). Results from the ICD-10 field trial of the Diagnostic Criteria for Research in German-speaking countries [J]. Psychopathology,1996,29(5):274-279.
[16] Rose SC,Weber KD,Collen JB,et al. The diagnosis andmanagement of concussion in children and adolescents [J]. Pediatr Neurol,2015,53(2):108-118.
[17] Teasdale G,Maas A,Lecky F,et al. The Glasgow Coma Scale at 40 years:standing the test of time [J]. Lancet Neurol,2014,13(8):844-854.
[18] Mc Innes K,Friesen CL,Mac Kenzie DE,et al. Mild Traumatic Brain Injury(m TBI)and chronic cognitive impairment:A scoping review [J]. PLoS One,2017,12(4):e0174847.
[19] Tator CH,Davis H. The post concussion syndrome in sports and recreation:clinical features and demography in 138 athletes [J]. Neurosurgery,2014,75(Suppl 4):S106-S112.
[20] Barlow KM,Crawford S,Stevenson A,et al. Epidemiology of postconcussion syndrome in pediatric mild traumatic brain injury [J]. Pediatrics,2010,126(2):e374-e381.
[21] Babcock L,Byczkowski T,Wade SL,et al. Predicting post concussion syndrome after mild traumatic brain injury in children and adolescents who present to theemergency department [J]. JAMA Pediatr,2013,167(2):156-161.
[22] Heyer GL,Schaffer CE,Rose SC,et al. Specific factors influence postconcussion symptom duration among youth referred to a sports concussion clinic [J]. J Pediatr,2016,174:33-38.
[23] Eisenberg MA,Andrea J,Meehan W,et al. Time intervalbetween concussions and symptom duration [J]. Pediatrics,2013,132(1):8-17.
[24] Morgan CD,Zuckerman SL,Lee YM,et al. Predictors of post concussion syndrome after sports-related concussion in young athletes:a matched case-control study [J]. Neurosurg Pediatr,2015,15(6):589-598.
[25] Meares S,Shores EA,Taylor AJ,et al. The prospective course of postconcussion syndrome:the role of mild traumatic brain injury [J]. Neuropsychology,2011,25(4):454-465.
[26] Ponsford J,Cameron P,Fitzgerald M,et al. Predictors of postconcussivesymptoms 3 months after mild traumatic brain injury [J]. Neuropsychology,2012,26(3):304-313.
[27] Mickeviciene D,Schrader H,Nestvold K,et al. A controlled historical cohort study on the post-concussion syndrome [J]. Eur J Neurol,2002,9(6):581-587.
[28] Mickeviciene D,Schrader H,Obelieniene D,et al. A controlled prospective inception cohort study on the post-concussion syndrome outside the medicolegal context [J]. Eur J Neurol,2004,11(6):411-419.