类风湿关节炎中的外泌体及其作用研究进展

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摘要本文通过回顾并分析类风湿关节炎（RA）中外泌体相关研究发现，外泌体不仅可作为RA的生物标志物，还通过分泌炎症因子、表达特殊膜蛋白、释放致炎微RNA等方式加重炎症过程并在一定程度上造成骨质破坏，参与RA的发生、发展过程；另一方面，部分外泌体还具有抗炎、促进软骨修复、递送治疗药物等积极作用，可加以利用，使期成为治疗RA的工具和手段。本文为今后进一步研究如何遏制RA发生、发展不利的外泌体及如何利用对治疗RA有益的外泌体指明了方向。

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	孙勇1
	2 赵创3 刘志丹1
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关键词 ：类风湿关节炎, 外泌体, 细胞外囊泡, 微RNA, 炎症, 骨质破坏, 药物递送系统

Abstract：In this paper, we reviewed and analyzed the findings related to exosomes in rheumatoid arthritis (RA). Exosomes can not only be used as disease biomarkers for RA, it also aggravates the inflammatory process and causes bone destruction to a certain extent by secreting inflammatory factors, expressing special membrane proteins and releasing inflammatory microRNA, participate in the occurrence and development of RA. On the other hand, some exosomes also have anti-inflammatory, promoting cartilage repair, delivering therapeutic drugs and other positive effects, it can be used as a tool and means to treat RA. This paper points out the direction for further research on how to curb the exosomes that are unfavorable to the occurrence and development of RA and how to utilize the exosomes that are beneficial to the treatment of RA.

Key words： Rheumatoid arthritis Exosome Extracellular vesicle MicroRNA Inflammation Bone destruction Drug delivery system

基金资助:国家自然科学基金青年科学基金项目（81904284）；
上海市人才发展资金资助项目（2020086）；
上海市宝山区中西医结合医院院级重点专科培育项目康复医学科（BSYYZ DZK-2019-04）。

通讯作者: 刘志丹（1981.8-），男，博士，副主任医师，硕士生导师；研究方向：关节病的中西医结合治疗。

作者简介: 孙勇（1989.7-），男，上海中医药大学康复医学院2017级中西医结合康复专业在读硕士研究生；研究方向：中西医结合康复。

引用本文:

孙勇1,2 赵创3 刘志丹1,2. 类风湿关节炎中的外泌体及其作用研究进展[J]. 中国医药导报, 2021, 18(26): 34-38.
SUN Yong1,2 ZHAO Chuang3 LIU Zhidan1,2. Advances in studies on exosomes and their roles in rheumatoid arthritis. 中国医药导报, 2021, 18(26): 34-38.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I26/34

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