Changes and clinical significance of PCT, CRP and coagulation function in patients with incision infection after modified radical mastectomy for breast cancer
CHEN Dapeng
Department of Breast Surgery, Bozhou People’s Hospital, Anhui Province, Bozhou 236800, China
Abstract：Objective To analyze the changes and clinical significance of procalcitonin (PCT), C-reactive protein (CRP), coagulation function indexes in patients with incision infection after modified radical mastectomy for breast cancer. Methods Clinical data of 125 breast cancer patients admitted to Bozhou People’s Hospital from June 2017 to October 2020 were retrospectively analyzed. Patients in both groups received modified radical mastectomy for breast cancer, and they were divided into infected group (65 cases) and uninfected group (60 cases) according to whether incision infection occurred after surgery. The changes of PCT, CRP, interleukin (IL) -5, activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen (FIB) in the operation time, hospitalization time, before and after operation were compared between the two groups. Results The operation time and hospitalization time of the infected group were longer than those of the uninfected group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in the levels of serum inflammatory between the two groups before operation (P ＞ 0.05). The levels of PCT, CPR, and IL-5 after operation in both groups were increased compared with those before operation, and those in the infected group were higher than those in the uninfected group (all P ＜ 0.05). There was no significant difference in the level of coagulation function between the two groups before operation (P ＞ 0.05). The levels of APTT and PT after operation in both groups were increased compared with those before operation, while FIB was decreased. The levels of APTT and PT in the infected group were lower than those in the uninfected group, while the level of FIB was higher than that in the uninfected group, with statistical significance (all P ＜ 0.05). Conclusion The levels of serum PCT, CPR and coagulation function can be used as effective indicators to predict incision infection after modified radical mastectomy for breast cancer.
陈大鹏. 乳腺癌改良根治术后切口感染患者PCT、CRP、凝血功能指标变化及临床意义[J]. 中国医药导报, 2021, 18(23): 104-107.
CHEN Dapeng. Changes and clinical significance of PCT, CRP and coagulation function in patients with incision infection after modified radical mastectomy for breast cancer. 中国医药导报, 2021, 18(23): 104-107.
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