Expression levels of serum pentraxin 3 and fibroblast growth factor 2 in patients with chronic heart failure and their correlation with myocardial remodeling and cardiac function
YU Hongbo1 LIU Yaqun2 YIN Dong3
1.Department of Cardiology, Qinhuangdao Jungong Hospital, Hebei Province, Qinhuangdao 066000, China;
2.Department of Neurology, Qinhuangdao Jungong Hospital, Hebei Province, Qinhuangdao 066000, China;
3.Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 100000, China
Abstract：Objective To detect the expression levels of serum pentagerin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with chronic heart failure (CHF), and to analyze the relationship between them and myocardial remodeling and cardiac function. Methods A total of 89 CHF patients in Qinhuangdao Jungong Hospital (hereinafter referred to as “our hospital”) from April 2018 to May 2019 were selected as the research subjects, and they were taken as the experimental group, and 90 healthy subjects in our hospital during the same period were taken as the control group. According to cardiac function status, CHF patients were divided into gradeⅠ(14 cases), grade Ⅱ(18 cases), grade Ⅲ (31 cases), and grade Ⅳ (26 cases). Serum PTX3 and FGF2 levels of the included subjects were detected. The relationship between cardiac function grade and serum PTX3 and FGF2 levels was analyzed. The relationship between the serum levels of PTX3, FGF2 and cardiac function and myocardial remodeling in CHF patients was analyzed. Results Serum levels of the serum level of PTX3 and FGF2 in experimental group were higher than those in the control group (P ＜ 0.05). In patients with CHF, compared with grade Ⅰ, serum levels of PTX3 and FGF2 were increased in patients with grades Ⅱ, Ⅲ, Ⅳ (P ＜ 0.05). Compared with grade Ⅱ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ(P ＜ 0.05). Compared with grade Ⅲ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ (P ＜ 0.05). Compared with gradeⅠ, the left ventricular end diastolic dimension (LVEDD) and left atrium diameter (LAD) in patients with grades Ⅱ, Ⅲ, Ⅳ, left ventricular mass index (LVMI) in patients with grade Ⅳ were increased, left ventricular cardiac output (LVCO) in patients with grades Ⅲ, Ⅳ, left ventricular ejection fraction (LVEF) and left ventricular reconstruction index (LVRI) in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅱ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO in patients with gradesⅢ, Ⅳ, the LVEF in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅲ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO and LVEF were decreased (P ＜ 0.05). Serum level of PTX3 in CHF patients was positively correlated with LVEDD and LVMI, and negatively correlated with LVEF and LVCO (P ＜ 0.05); the level of FGF2 was positively correlated with LVEDD, LAD and LVMI, and negatively correlated with LVEF and LVERI (P ＜ 0.05). Conclusion The elevated serum levels of PTX3 and FGF2 in CHF patients are closely related to cardiac function and myocardial remodeling indexes, and affect the severity of the disease.
于红波1 刘亚群2 尹栋3. 慢性心力衰竭患者血清正五聚蛋白3、成纤维细胞生长因子2的表达水平及其与心肌重构和心功能的相关性[J]. 中国医药导报, 2021, 18(23): 68-71,99.
YU Hongbo1 LIU Yaqun2 YIN Dong3. Expression levels of serum pentraxin 3 and fibroblast growth factor 2 in patients with chronic heart failure and their correlation with myocardial remodeling and cardiac function. 中国医药导报, 2021, 18(23): 68-71,99.
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