慢性心力衰竭患者血清正五聚蛋白3、成纤维细胞生长因子2的表达水平及其与心肌重构和心功能的相关性

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摘要目的检测慢性心力衰竭（CHF）患者血清正五聚蛋白3（PTX3）、成纤维细胞生长因子2（FGF2）的表达水平，分析二者与心肌重构和心功能的关系。方法选取2018年4月至2019年5月秦皇岛军工医院（以下简称“我院”）89例CHF患者为研究对象，并将其作为实验组，我院同期90名健康体检者作为对照组。根据患者心功能状态，将CHF患者分成Ⅰ级（14例）、Ⅱ级（18例）、Ⅲ级（31例）、Ⅳ级（26例）。检测纳入对象血清中PTX3、FGF2水平；分析心功能分级与血清中PTX3、FGF2水平的关系；分析CHF患者血清中PTX3、FGF2水平与心功能、心肌重构指标关系。结果实验组血清PTX3、FGF2水平高于对照组（P ＜ 0.05）。CHF患者中，与Ⅰ级比较，Ⅱ、Ⅲ、Ⅳ级患者血清中PTX3、FGF2水平升高（P ＜ 0.05）；与Ⅱ级比较，Ⅳ级患者血清中PTX3、FGF2水平升高（P ＜ 0.05）；与Ⅲ级比较，Ⅳ级患者血清中PTX3水平升高（P ＜ 0.05）。与Ⅰ级比较，Ⅱ、Ⅲ、Ⅳ级患者左心室舒张末期内径（LVEDD）、左心房内径（LAD），Ⅳ级患者左心室质量指数（LVMI）升高，Ⅲ、Ⅳ级患者左心室心输出量（LVCO），Ⅳ级患者左心室射血分数（LVEF）、左室重构指数（LVRI）降低（P ＜ 0.05）。与Ⅱ级比较，Ⅳ级患者LVEDD、LAD升高，Ⅲ、Ⅳ级患者LVCO，Ⅳ级患者LVEF降低（P ＜ 0.05）。与Ⅲ级比较，Ⅳ级患者LVEDD、LAD升高，LVEF、LVCO降低（P ＜ 0.05）。CHF患者血清中PTX3水平与LVEDD、LVMI呈正相关，与LVEF、LVCO呈负相关（P ＜ 0.05）；FGF2水平与LVEDD、LAD、LVMI呈正相关，与LVEF、LVRI呈负相关（P ＜ 0.05）。结论 CHF患者血清中PTX3、FGF2水平升高，与心功能、心肌重构指标关系密切，影响疾病严重程度。

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	于红波1 刘亚群2 尹栋3

关键词 ：慢性心力衰竭, 正五聚蛋白3, 成纤维细胞生长因子2, 心肌重构, 心功能

Abstract：Objective To detect the expression levels of serum pentagerin 3 (PTX3) and fibroblast growth factor 2 (FGF2) in patients with chronic heart failure (CHF), and to analyze the relationship between them and myocardial remodeling and cardiac function. Methods A total of 89 CHF patients in Qinhuangdao Jungong Hospital (hereinafter referred to as “our hospital”) from April 2018 to May 2019 were selected as the research subjects, and they were taken as the experimental group, and 90 healthy subjects in our hospital during the same period were taken as the control group. According to cardiac function status, CHF patients were divided into gradeⅠ(14 cases), grade Ⅱ(18 cases), grade Ⅲ (31 cases), and grade Ⅳ (26 cases). Serum PTX3 and FGF2 levels of the included subjects were detected. The relationship between cardiac function grade and serum PTX3 and FGF2 levels was analyzed. The relationship between the serum levels of PTX3, FGF2 and cardiac function and myocardial remodeling in CHF patients was analyzed. Results Serum levels of the serum level of PTX3 and FGF2 in experimental group were higher than those in the control group (P ＜ 0.05). In patients with CHF, compared with grade Ⅰ, serum levels of PTX3 and FGF2 were increased in patients with grades Ⅱ, Ⅲ, Ⅳ (P ＜ 0.05). Compared with grade Ⅱ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ(P ＜ 0.05). Compared with grade Ⅲ, the serum levels of PTX3 and FGF2 were increased in patients with grade Ⅳ (P ＜ 0.05). Compared with gradeⅠ, the left ventricular end diastolic dimension (LVEDD) and left atrium diameter (LAD) in patients with grades Ⅱ, Ⅲ, Ⅳ, left ventricular mass index (LVMI) in patients with grade Ⅳ were increased, left ventricular cardiac output (LVCO) in patients with grades Ⅲ, Ⅳ, left ventricular ejection fraction (LVEF) and left ventricular reconstruction index (LVRI) in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅱ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO in patients with gradesⅢ, Ⅳ, the LVEF in patients with grade Ⅳ were decreased (P ＜ 0.05). Compared with grade Ⅲ, the LVEDD and LAD in patients with grade Ⅳ were increased, the LVCO and LVEF were decreased (P ＜ 0.05). Serum level of PTX3 in CHF patients was positively correlated with LVEDD and LVMI, and negatively correlated with LVEF and LVCO (P ＜ 0.05); the level of FGF2 was positively correlated with LVEDD, LAD and LVMI, and negatively correlated with LVEF and LVERI (P ＜ 0.05). Conclusion The elevated serum levels of PTX3 and FGF2 in CHF patients are closely related to cardiac function and myocardial remodeling indexes, and affect the severity of the disease.

Key words： Chronic heart failure Pentraxin 3 Fibroblast growth factor 2 Myocardial remodeling Cardiac function

基金资助:河北省秦皇岛市科学技术研究与发展计划项目（201805A097）；
北京市科技计划项目（Z161100000516095）。

引用本文:

于红波1 刘亚群2 尹栋3. 慢性心力衰竭患者血清正五聚蛋白3、成纤维细胞生长因子2的表达水平及其与心肌重构和心功能的相关性[J]. 中国医药导报, 2021, 18(23): 68-71,99.
YU Hongbo1 LIU Yaqun2 YIN Dong3. Expression levels of serum pentraxin 3 and fibroblast growth factor 2 in patients with chronic heart failure and their correlation with myocardial remodeling and cardiac function. 中国医药导报, 2021, 18(23): 68-71,99.

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