复方伤痛胶囊联合射频消融术治疗腰椎间盘突出症的效果

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摘要目的观察复方伤痛胶囊联合射频消融术治疗腰椎间盘突出症（LDH）的效果。方法选取2018年9月至2019年4月右江民族医学院收治的124例LDH患者，将其按照随机数字表法分为对照组和观察组，每组62例。对照组术后予射频消融术口服双氯芬酸钠缓释片，观察组术后予射频消融术口服复方伤痛胶囊。10 d为1个疗程。比较两组疼痛数字分级法（NRS）评分、腰椎Oswestry功能障碍指数（ODI）评分和临床疗效，酶联免疫吸附试验测定血清中炎症因子[白细胞介素（IL）-1β、IL-6、IL-8、肿瘤坏死因子-α（TNF-α）]，记录不良反应发生情况。结果治疗后，两组NRS评分、ODI评分及IL-1β、IL-6、IL-8、TNF-α水平均较治疗前下降，差异有统计学意义（P ＜ 0.05）；两组NRS评分、ODI评分及IL-1β、IL-6、IL-8、TNF-α水平比较，差异无统计学意义（P ＞ 0.05）。两组优良率比较，差异无统计学意义（P ＞ 0.05）。观察组不良反应发生率低于对照组，差异有统计学意义（P ＜ 0.05）。结论复方伤痛胶囊治疗LDH安全且有效，值得临床推广。

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	黄锦益邓军▲ 韦克文志谦兰剑

关键词 ：复方伤痛胶囊, 射频消融术, 腰椎间盘突出症, 疼痛, 炎症

Abstract：Objective To observe the effect of Compound Shangtong Capsules combined with radiofrequency ablation in the treatment of lumbar disc herniation (LDH). Methods A total of 124 LDH patients admitted to Youjiang Medical University for Nationalities from September 2018 to April 2019 were selected and they were divided into control group and observation group according to random number table method, with 62 cases in each group. The control group received oral Diclofenac Sodium Sustained-release Tablets after radiofrequency ablation, and the observation group received oral Compound Shangtong Capsules after radiofrequency ablation. The treatment course was ten days. Numerical rating scale (NRS) score, lumbar Oswestry disability index (ODI) score and clinical efficacy were compared between the two groups. The inflammatory factors (interleukin [IL]-1β, IL-6, IL-8, tumor necrosis factor-α [TNF-α]) in serum were determined by enzyme linked immunosorbent assay, and the incidence of adverse reactions was recorded. Results After treatment, NRS score, ODI score, IL-1β, IL-6, IL-8, TNF-α levels in two groups were decreased compared with before treatment, with statistical significance (P ＜ 0.05). There was no significant difference in NRS score, ODI score, IL-1β, IL-6, IL-8 and TNF-α levels between the two groups (P ＞ 0.05). There was no statistical significance in the excellent and good rates between the two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Compound Shangtong Capsules are safe and effective in the treatment of LDH, which were worthy of clinical promotion.

Key words： Compound Shangtong Capsules Radiofrequency ablation Lumbar disc herniation Pain Inflammation

基金资助:广西壮族自治区百色市科学研究与技术开发计划课题（百科20201711）。

通讯作者: ▲通讯作者

引用本文:

黄锦益邓军▲ 韦克文志谦兰剑. 复方伤痛胶囊联合射频消融术治疗腰椎间盘突出症的效果[J]. 中国医药导报, 2021, 18(21): 88-91.
HUANG Jinyi DENG Jun▲ WEI Ke WEN Zhiqian LAN Jian. Effect of Compound Shangtong Capsules combined with radiofrequency ablation in the treatment of lumbar disc herniation. 中国医药导报, 2021, 18(21): 88-91.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I21/88

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