Clinical effect of intensive hypoglycemic regimens in the treatment of patients with diabetes mellitus type 2 complicated with ischemic stroke
Nadila WEI Wei LU Xueling
Department of General Endocrinology, the Seventh Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830028, China
Abstract：Objective To observe the effect of intensive hypoglycemic regimens in the treatment of patients with diabetes mellitus type 2 complicated with ischemic stroke. Methods A total of 100 patients with diabetes mellitus type 2 complicated with ischemic stroke admitted to the Seventh Affiliated Hospital of Xinjiang Medical University from May 2019 to January 2020 were selected and divided into the enhanced group (glycosylated hemoglobin > 9.0%, 50 cases) and the control group (glycosylated hemoglobin ≤9.0%, 50 cases) according to the glycosylated hemoglobin condition. Continuous subcutaneous insulin infusion was given to the intensive group, which was adjusted to multiple subcutaneous insulin injections after discharge. After three months of oral hypoglycemic drug treatment in the control group, if glycosylated hemoglobin ≥7.0%, the treatment plan was adjusted until glycosylated hemoglobin ＜7.0%. The treatment time of both groups was six months. Biochemical indexes were compared between the two groups at admission and after six months of treatment, and neurological function was compared between the two groups after six months of treatment. Results After six months of treatment, the levels of fasting blood glucose, two hours postprandial blood glucose, glycated hemoglobin, and homocysteine in the enhanced group were lower than those at admission, while the levels of two hours postprandial blood glucose and homocysteine in the control group were lower than those at admission, with statistical significance (P ＜ 0.05). The levels of two hours postprandial blood glucose and glycosylated hemoglobin in the enhanced group were higher than those in the control group at admission, with statistical significance (P ＜ 0.05). After six months of treatment, fasting blood glucose and two hours postprandial blood glucose in the enhanced group were higher than those in the control group, and creatinine was lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, the neurological function was compared between two groups, and the difference was statistically significant (P ＜ 0.05). Conclusion Intensive hypoglycemic regimens can improve the recovery of neurological function in patients with diabetes after stroke.
娜迪拉 魏巍 卢雪玲. 2型糖尿病合并缺血性脑卒中患者采用强化降糖方案治疗的临床效果[J]. 中国医药导报, 2021, 18(21): 67-70.
Nadila WEI Wei LU Xueling. Clinical effect of intensive hypoglycemic regimens in the treatment of patients with diabetes mellitus type 2 complicated with ischemic stroke. 中国医药导报, 2021, 18(21): 67-70.
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