Abstract：Radioactive lung injury is a possible adverse event in patients with thoracic cancer receiving radiotherapy, and it is also one of the dose-limiting toxicity to maximize the radiotherapy benefit in patients with thoracic cancer under the premise of ensuring radiotherapy safety. The influencing factors of radiation lung injury include radiological factors, tumor factors and patient factors. To elucidate the influencing factors of radiation lung injury will provide a theoretical basis for reducing the incidence of radiation lung injury in tumor patients receiving chest radiotherapy.
熊中奎1,2 郎娟3 王思本1. 放射性肺损伤的影响因素的研究进展[J]. 中国医药导报, 2021, 18(21): 42-45.
XIONG Zhongkui1,2 LANG Juan3 WANG Siben1. Research progress on the influencing factors of radiation lung injury. 中国医药导报, 2021, 18(21): 42-45.
[1] 鲍艳红，黄常新.放射性肺炎的发病机制及其防治研究进展[J].实用医学杂志，2015，31（21）：3621-3623.
[2] 王诚，顾佳乐，邓清华，等.VMAT下肺等效均匀剂量预测RP 价值研究[J].中华放射肿瘤学杂志，2017，26（7）：249-253.
[3] von Reibnitz D，Yorke ED，Oh JH，et al. Predictive Modeling of Thoracic Radiotherapy Toxicity and the Potential Role of Serum Alpha-2-Macroglobulin [J]. Front Oncol，2020，10：1395.
[4] Shaikh T，Churilla TM，Monpara P，et al. Risk of radiation pneumonitis in patients receiving taxane-based trimodality therapy for locally advanced esophageal cancer [J]. Pract Radiat Oncol，2016，6（6）：388-394.
[5] Wen G，Tan YT，Lan XW，et al. New Clinical Features and Dosimetric Predictor Identification for Symptomatic Radiation Pneumonitis after Tangential Irradiation in Breast Cancer Patients [J]. J Cancer，2017，8（18）：3795-3802.
[6] Alharbi M，Janssen S，Golpon H，et al. Temporal and spatial dose distribution of radiation pneumonitis after concurrent radiochemotherapy in stage Ⅲ non-small cell cancer patients [J]. Radiat Oncol，2017，12（10）：165.
[7] Shi S，Zeng Z，Ye L，et al. Risk Factors Associated With Symptomatic Radiation Pneumonitis After Stereotactic Body Radiation Therapy for Stage Ⅰ Non-Small Cell Lung Cancer [J]. Technol Cancer Res Treat，2017，16（3）：316-320.
[8] Zhao J，Yorke ED，Li L，et al. Simple Factors Associated With Radiation-Induced Lung Toxicity After Stereotactic Body Radiation Therapy of the Thorax：A Pooled Analysis of 88 Studies [J]. Int J Radiat Oncol Biol Phys，2016，95（5）：1357-1366.
[9] Nakamura M，Nishimura H，Nakayama M，et al. Dosimetric factors predicting radiation pneumonitis after CyberKnife stereotactic body radiotherapy for peripheral lung cancer [J]. Br J Radiol，2016，89（1068）：20160560.
[10] Nakajima M，Yamamoto N，Hayashi K，et al. Carbon-ion radiotherapy for non-small cell lung cancer with interstitial lung disease： a retrospective analysis [J]. Radiat Oncol，2017，12：144.
[11] Zhao Y，Chen L，Zhang S，et al. Predictive factors for acute radiation pneumonitis in postoperative intensity modulated radiation therapy and volumetric modulated arc therapy of esophageal cancer [J]. Thorac Cancer，2015， 6：49-57.
[12] Kim K，Lee J，Cho Y，et al. Predictive factors of symptomatic radiation pneumonitis in primary and metastatic lung tumors treated with stereotactic ablative body radiotherapy [J]. Radiat Oncol J，2017，35（2）：163-171.
[13] Jeba J，Isiah R，Subhashini J，et al. Radiation Pneumonitis After Conventional Radiotherapy For Breast Cancer：A Prospective Study [J]. J Clin Diagn Res，2015，9（7）：XC01-XC05.
[14] Ling DC，Hess CB，Chen AM，et al. Comparison of Toxicity Between Intensity-Modulated Radiotherapy and 3-Dimensional Conformal Radiotherapy for Locally Advanced Non-small-cell Lung Cancer [J]. Clin Lung Cancer，2016，17（1）：18-23.
[15] Hu X，He W，Wen S，et al. Is IMRT Superior or Inferior to 3DCRT in Radiotherapy for NSCLC? A Meta-Analysis [J]. PLoS One 2016，11（4）：e0151988.
[16] 喻冰琪，王谨，徐裕金，等.放疗技术与放射性肺损伤：高剂量小体积还是低剂量大体积？[J].中国肺癌杂志，2015，18（12）：752-757.
[17] Ferrero C，Badellino S，Filippi AR，et al. Pulmonary function and quality of life after VMAT-based stereotactic ablative radiotherapy for early stage inoperable NSCLC：a prospective study [J]. Lung Cancer，2015，89（3）：350-356.
[18] Ono T，Hareyama M，Nakamura T，et al. The clinical results of proton beam therapy in patients with idiopathic pulmonary fibrosis： a single center experience [J]. Radiat Oncol，2016，11：56.
[19] Hayashi K，Yamamoto N，Karube M，et al. Prognostic analysis of radiation pneumonitis： carbon-ion radiotherapy in patients with locally advanced lung cancer [J]. Radiat Oncol，2017，12（1）：91.
[20] Sumita K，Harada H，Asakura H，et al. Re-irradiation for locoregionally recurrent tumors of the thorax： a single-institution，retrospective study [J]. Radiat Oncol，2016， 11：104.
[21] Hayes JT，Chen AM，Daly ME，et al. Risk of Pneumonitis after Stereotactic Body Radiation Therapy in Patients with Prior Anatomic Lung Resection [J]. Clin Lung Cancer，2015，16（5）：379-384.
[22] Chiang CL，Chen YW，Wu MH，et al. Radiation recall pneumonitis induced by epidermal growth factor receptor-tyrosine kinase inhibitor in patients with advanced nonsmall-cell lung cancer [J]. J Chin Med Assoc，2016， 79（5）：248-255.
[23] 钟琼，邓江华，曾爱群，等.非小细胞肺癌三维适形调强放疗后放射性肺炎发生的相关因素分析[J].实用癌症杂志，2014，29（5）：550-554.
[24] 陈伟，宫帅，尹静静.肺癌放射治疗致放射性肺炎的临床疗效分析[J].中国实用医药，2014，9（27）：7-9.
[25] Kang KH，Okoye CC，Patel RB，et al. Complications from Stereotactic Body Radiotherapy for Lung Cancer [J]. Cancers（Basel），2015，7：981-1004.
[26] Yao B，Wang YD，Liu QZ. Radiation pneumonitis in non-small-cell lung cancer patients treated with helical tomotherapy [J]. Niger J Clin Pract，2016，19：25-29.
[27] Uchida Y，Tsugawa T，Tanaka-Mizuno S，et al. Exclusion of emphysematous lung from dose-volume estimates of risk improves prediction of radiation pneumonitis [J]. Radiat Oncol，2017，12（1）：160.
[28] Inoue T，Shiomi H，Oh RJ. Stereotactic body radiotherapy for Stage Ⅰ lung cancer with chronic obstructive pulmonary disease：special reference to survival and radiation-induced pneumonitis [J]. J Radiat Res，2015，56（4）：727-734.
[29] Hung SK，Chen YC，Chiou WY，et al. Irradiation enhanced risks of hospitalised pneumonopathy in lung cancer patients：a population-based surgical cohort study [J]. BMJ Open，2017，7（9）：e015022.
[30] Zhou Z，Song X，Wu A，et al. Pulmonary emphysema is a risk factor for radiation pneumonitis in NSCLC patients with squamous cell carcinoma after thoracic radiation therapy [J]. Sci Rep，2017，7（1）：2748.
[31] Ozawa Y，Abe T，Omae M，et al. Impact of Preexisting Interstitial Lung Disease on Acute，Extensive Radiation Pneumonitis： Retrospective Analysis of Patients with Lung Cancer [J]. PLoS One，2015，10（10）：e0140437.
[32] Rades D，Werner EM，Glatzel E，et al. Pneumonitis after radiotherapy for lung cancer（PARALUC）：an interventional study to create a symptom-based scoring system for identification of patients developing radiation pneumonitis [J]. BMC Cancer，2020，20：785.
京公网安备 11010502046598号