Research progress on immune regulation mechanism of external therapy of traditional Chinese medicine on inflammatory bowel disease
JIAO Yi1 ZHANG Yingqi1 LU Mengqian1 YU Tianyuan1 LIU Zhifeng1 LIU Di2
1.School of Acupuncture and Moxibustion and Massage, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Acupuncture and Moxibustion, Oriental Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
Abstract：Inflammatory bowel disease (IBD) is an autoimmune disease with lesions located in the mucosa of colon and rectum. At present, IBD is believed to be mostly related to diet, mood, infection and immunity, among which immunity is the most studied. Four traditional Chinese medicine external treatment methods are mostly selected clinically, including acupuncture, moxa-wool moxibustion, massage and traditional Chinese medicine enema therapy. In this paper, from the point of inflammation and immunity of IBD, the immune regulation mechanism of external treatment of Chinese medicine on IBD is discussed. The external treatment of traditional Chinese medicine can regulate the inflammatory immune response of the body through multiple targets and channels, so as to achieve the state that the vital qi is stored inside and the pathogen cannot be dried. The four kinds of external therapy intervention methods involved in this paper are different, and the mechanisms involved are also different. Acupuncture provides mechanical stimulation, moxa-wool moxibustion provides warm stimulation, and massage provides both mechanical stimulation and warm stimulation, and traditional Chinese medicine enema therapy provides drug stimulation. Acupuncture and moxa-wool moxibustion are both involved in balancing immune microenvironment and anti-inflammatory mechanism. Acupuncture is also involved in anti-oxidative stress response, anti-endoplasmic reticulum stress response and the alleviation of visceral sensitivity. Massage mainly provides sufficient morphological basis, and traditional Chinese medicine enema therapy regulates immune disorders through direct contact with the lesion site.
焦谊1 张英琦1 鲁梦倩1 于天源1 刘志凤1 刘迪2. 中医外治法对炎性肠病的免疫调节机制研究进展[J]. 中国医药导报, 2021, 18(21): 38-41.
JIAO Yi1 ZHANG Yingqi1 LU Mengqian1 YU Tianyuan1 LIU Zhifeng1 LIU Di2. Research progress on immune regulation mechanism of external therapy of traditional Chinese medicine on inflammatory bowel disease. 中国医药导报, 2021, 18(21): 38-41.
[1] Ng SC，Shi HY，Hamidi N，et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century：a systematic review of population-based studies [J]. Lancet，2017，390（10114）：2769-2778.
[2] Knowles SR，Keefer L，Wilding H，et al. Quality of Life in Inflammatory Bowel Disease：A Systematic Review and Meta-analyses-Part Ⅱ [J]. Inflamm Bowel Dis，2018，24（5）：966-976.
[3] Guan Q. A Comprehensive Review and Update on the Pathogenesis of Inflammatory Bowel Disease [J]. J Immunol Res，2019，2019：7247238.
[4] Zhu J，Paul WE. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors [J]. Immunol Rev，2010，238（1）：247-262.
[5] Sun J，Zhang H，Wang C，et al. Regulating the Balance of Th17/Treg via Electroacupuncture and Moxibustion：An Ulcerative Colitis Mice Model Based Study [J]. Evid Based Complement Alternat Med，2017，2017：7296353.
[6] 乔翠霞，赵刚，张立泽，等.基于Toll样受体4/髓样分化因子88/核因子-κB通路探讨电针对溃疡性结肠炎大鼠的干预机制[J].针刺研究，2020，45（3）：180-187，201.
[7] 李皓月，梁浩.电针天枢穴对溃疡性结肠炎大鼠TLR4/NF-κB信号通路的影响[J].新中医，2018，50（12）：20-24.
[8] 吴阳阳，刘明江，殷韶杰，等.针刺对溃疡性结肠炎大鼠氧化应激和内质网应激的影响[J].针刺研究，2020，45（1）：8-14.
[9] Goes AC，Pinto FM，Fernandes GC，et al. Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice [J]. Acta Cir Bras，2014，29（12）：787-793.
[10] Su YS，He W，Wang C，et al.“Intensity-response”effects of Electroacupuncture on Gastric Motility and Its Underlying Peripheral Neural Mechanism [J]. Evid Based Complement Alternat Med，2013，2013：535742.
[11] 尹业辉.电针对直结肠高敏感模型小鼠脊神经节神经元的基因调控研究[D].北京：中国中医科学院，2019.
[12] 陈艳萍.针灸对溃疡性结肠炎大鼠Th1/Th2免疫平衡的影响[J].针刺研究，2016，41（3）：210-214.
[13] Zhao C，Bao C，Li J，et al. Moxibustion and Acupuncture Ameliorate Crohn’s Disease by Regulating the Balance between Th17 and Treg Cells in the Intestinal Mucosa [J]. Evid Based Complement Alternat Med，2015，2015：938054.
[14] 于千惠，李丽红，卢雨微，等.穴位埋线联合艾灸对溃疡性结肠炎大鼠结肠黏膜的抗炎修复作用[J].针刺研究，2020，45（4）：305-309.
[15] 杨玲，黄艳，黄任佳，等.艾灸预处理天枢穴对溃疡性结肠炎大鼠结肠TLR4/TRIF信号通路调节作用的研究[J].上海针灸杂志，2019，38（8）：819-826.
[16] 赵继梦，吴焕淦，陆嫄，等.隔药灸对溃疡性结肠炎大鼠结肠NF-κB和STAT3活性的免疫调节机制[J].世界科学技术-中医药现代化，2018，20（9）：1579-1584.
[17] Li JA，Wang YD，Wang K，et al. Downregulation of miR-214-3p May Contribute to Pathogenesis of Ulcerative Colitis via Targeting STAT6 [J]. Biomed Res Int，2017，2017：8524972.
[18] 顾沐恩，赵继梦，吴焕淦，等.隔姜灸天枢穴对UC大鼠结肠组织的miRNA表达谱的影响[J].上海针灸杂志，2020，39（6）：766-774.
[19] 邱悦，施睿，余芝，等.不同艾灸对大鼠血管舒缩功能调节与TRPV1 mRNA关系的研究[J].辽宁中医杂志，2016， 43（9）：1984-1987，2015.
[20] 穆敬平，刘莉，周立志，等.艾灸对炎症性肠病大鼠结肠黏膜肥大细胞和TRPV1的影响[J].辽宁中医杂志，2014， 41（8）：1749-1752.
[21] 郑桂芝，李晗，吴焕淦，等.温和灸皮肤神经性TRPV1启动机制及对内脏痛的效应机制研究[J].世界中医药，2016，11（12）：2515-2520.
[22] 周攀，张建斌，王玲玲，等.不同灸温的艾灸抗炎效应及TRPV1作用机制研究[J].中国中医基础医学杂志，2015， 21（9）：1143-1145.
[23] 杨梦凡.推拿结合西药治疗对湿热型溃疡性结肠炎缓解期的疗效观察[D].南京：南京中医药大学，2014.
[24] 解小波，王继红.基于不同频率摩腹法干预对脾虚型家兔十二指肠黏膜细胞病理差异分析[J].中华中医药杂志，2018，33（2）：686-689.
[25] 陈玉梅，王继红，郭锐伟.不同频率摩腹对脾虚家兔空肠黏膜形态学的影响研究[J].辽宁中医杂志，2018，45（4）：864-867，896.
[26] 郭锐伟，王继红，陈玉梅.不同频率摩腹对脾虚家兔回肠黏膜形态学的影响研究[J].中华中医药学刊，2018， 36（3）：648-650.
[27] 赵祥，杨铁军，李华南，等.腹部推拿对肠动力障碍兔结肠组织中ENS-ICC网络结构的影响[J].中医外治杂志，2017，26（4）：7-8.
[28] 李华南，韩一豪，刘洋，等.腹部推拿对慢性疲劳综合征模型大鼠海马区Ca2+浓度及MAPK、ERK蛋白表达的影响[J].辽宁中医杂志，2019，46（9）：1817-1820.
[29] Guo SM，Tong HB，Bai LS，et al. Effect of traditional Chinese medicinal enemas on ulcerative colitis of rats [J]. World J Gastroenterol，2004，10（13）：1914-1917.
[30] 于姣，何瑾瑜，张蕾.中药灌肠对溃疡性结肠炎患者的临床疗效及中性粒细胞与淋巴细胞比值的影响[J].中国卫生检验杂志，2017，27（20）：2965-2967.
[31] 拉扎提·巴合提.血竭地榆灌肠方对血瘀肠络型溃疡性结肠炎TOLL样受体4信号通路的影响[D].北京：北京中医药大学，2015.
[32] 吴昊.清肠化湿方治疗溃疡性结肠炎临床疗效观察及对NF-κB、caspase-3和肠黏膜屏障的影响[D].南京：南京中医药大学，2014.
[33] 赵新芳，甘霞，林红，等.化毒愈肠方内服和灌肠治疗溃疡性结肠炎的疗效及对血清IL-22和IL-23的影响[J].中国实验方剂学杂志，2016，22（4）：178-181.
京公网安备 11010502046598号