Abstract：Objective To investigate the effect of preventive ileostomy in minimally invasive radical operation on clinical efficacy and anal function in patients with rectal cancer. Methods A total of 91 patients with rectal cancer who were diagnosed and treated in the People’s Hospital of Chizhou, Anhui Province from September 2017 to May 2020 were selected as the research subjects, and they were divided into observation group and control group according to the operative methods. The observation group (32 cases) received laparoscopic radical resection combined with ileostomy, while the control group (59 cases) received laparoscopic radical resection alone. Perioperative indexes, changes in gastrointestinal function, postoperative recovery, laboratory indexes, anal function score and complications were compared between the two groups. Results There were no significant differences in intestinal sound recovery time, exhaust time, starting feeding time, operation time, intraoperative blood loss, length of resected lesions and total amount of lymph node dissection between the two groups (P ＞ 0.05). The time of getting out of bed for the first time, the number of days of fluid rehydration after operation and the length of hospital stay in the observation group were shorter than those in the control group, with statistical significance (P ＜ 0.05). The levels of white blood cells and C-reactive protein 2 and 5 d after operation were higher than those before operation, and the levels of pre-albumin were lower than those before operation. The levels of white blood cells and C-reactive protein 5 d after operation were lower than those 2 d after operation, and the levels of pre-albumin were higher than those 2 d after operation, with statistical significance (P ＜ 0.05). The levels of white blood cells in observation group were higher than those in control group at the same time point, and the levels of C-reactive protein and pre-albumin in observation group were lower than those in control group at the same time point. The levels of white blood cells and C-reactive protein at 5 d after operation were lower than those in the control group at the same time point, and the levels of pre-albumin were higher than those in the control group at the same time point, with statistical significance (all P ＜ 0.05). The scores of anal function at 14 d, 3 and 6 months after operation in both groups were higher than those before operation; those at 3 and 6 months after operation were higher than those at 14 d, and those at 6 months after operation were higher than those at three months after operation, with statistical significance (all P ＜ 0.05). The scores of anal function in the observation group at 14 d and 6 months after operation were higher than those in the control group at the same time point, and the scores at 3 months after operation were lower than those in the control group at the same time point, with statistical significance (P ＜ 0.05). There was no significant difference in the total incidence of complication between the two groups (P ＞ 0.05). Conclusion In patients with rectal cancer, the preventive of ileostomy during minimally invasive radical operation is beneficial to improve the anal function of patients and promote the improvement of life quality.
时婕 花庶庆 陈云 李昕 汪伟. 微创根治术中预防性回肠末端造口对直肠癌患者临床疗效及肛门功能的影响[J]. 中国医药导报, 2021, 18(20): 91-95.
SHI Jie HUA Shuqing CHEN Yun LI Xin WANG Wei. Effect of preventive ileostomy in minimally invasive radical operation on clinical efficacy and anal function in patients with rectal cancer. 中国医药导报, 2021, 18(20): 91-95.
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