Effect of Huayu Tongluo Decoction on wound healing and blood flow index of dorsal foot artery in diabetic foot patients
HU Jinqing1,2 XIE Yonghua1,2 LI Lingli1,2 GU Ruixin1,2 WANG Yun1,2
1.Department of Chinese Medicine, Wuhan Fourth Hospital, Hubei Province, Wuhan 430032, China;
2.Department of Chinese Medicine, Pu’ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Province, Wuhan 430032, China
Abstract：Objective To investigate the effect of Huayu Tongluo Decoction on wound healing and hemodynamic indexes of dorsal foot artery in diabetic foot patients. Methods One hundred patients with diabetic foot in Wuhan Fourth Hospital from October 2016 to December 2018 were selected and divided into Huayu Tongluo Decoction group and Tongsaimai Tablet group according to random number table method, with 50 cases in each group. Huayu Tongluo Decoction group was treated with Huayu Tongluo Decoction on the basis of conventional treatment, while Tongsaimai Tablet group was treated with Tongsaimai Tablets on the basis of conventional treatment. Both groups were treated for four weeks. Clinical efficacy, ulcer area, Chinese medicine symptom score and hemodynamic indexes of dorsalis pedis artery [peak velocity(Vp), mean flow velocity (Vm), resistance index (RI), pulsatility index (PI)] were compared between two groups. Results Clinical effect of Huayu Tongluo Decoction group was better than that of Tongsaimai Tablet group, and the difference was statistically significant (P < 0.05). After treatment, the ulcer area of two groups were less than that before treatment, and Huayu Tongluo Decoction group was less than Tongsaimai Tablet group, the difference was statistically significant (P < 0.05). After treatment, the score of focus range, pain, swelling, numbness and limp in two groups were lower than those before treatment, and Huayu Tongluo Decoction group was lower than Tongsaimai Tablet group, and the differences were statistically significant (P < 0.05). After treatment, Vp and Vm of dorsalis pedis artery in two groups were faster than those before treatment, RI was lower than that before treatment, PI was higher than that before treatment, the differences were statistically significant (P < 0.05). While there were no significant differences between the two groups (P > 0.05). Conclusion Huayu Tongluo Decoction can effectively improve clinical symptoms of patients with diabetic foot ulcer and foot dorsal artery hemodynamic index, promote ulcer healing, and has no obvious toxic and side effects. It is a safe and effective method for the treatment of diabetic foot ulcer, which is worthy of clinical promotion.
胡锦庆1,2 谢永华1,2 李伶俐1,2 辜锐鑫1,2 王芸1,2. 化瘀通络汤对糖尿病足患者创面愈合及足背动脉血流指标的影响[J]. 中国医药导报, 2021, 18(19): 147-150,154.
HU Jinqing1,2 XIE Yonghua1,2 LI Lingli1,2 GU Ruixin1,2 WANG Yun1,2. Effect of Huayu Tongluo Decoction on wound healing and blood flow index of dorsal foot artery in diabetic foot patients. 中国医药导报, 2021, 18(19): 147-150,154.
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