Abstract：Drug-induced liver injury is the most common and serious adverse drug reactions, a case of lung cancer with brain metastases developed severe drug-induced cholestasis after oral Anlotinib combined with Temozolomide chemotherapy. Liver injury continued to progress after routine liver preservation and cholestasis improvement therapy, and improved after treatment with glucocorticoid. According to the literature review, there have been many cases of pathologically confirmed severe cholestasis or even vanishingbile duct syndrome after the application of Temozolomide, a few cases it can lead to death. Timing glucocorticoid therapy and adjusting glucocorticoid dosage according to the therapeutic effect can reduce liver inflammation and cholestasis and improve the prognosis of patients.
任玉莲 王磊 孙建光. 替莫唑胺联合安罗替尼化疗后肝损伤1例并文献复习[J]. 中国医药导报, 2021, 18(18): 176-178.
REN Yulian WANG Lei SUN Jianguang. A case report and literature review liver injury after chemotherapy with Temozolomide and Anlotinib. 中国医药导报, 2021, 18(18): 176-178.
[1] Chalasani NP，Hayashi PH，Bonkovsky HL，et al. ACG Clinical Guideline：the diagnosis and management of idiosyncratic drug-induced liver injury [J]. Am J Gastroenterol，2014，109（7）：950-966，967.
[2] 中华医学会肝病学分会药物性肝病学组.药物性肝损伤诊治指南[J].实用肝脏病杂志，2017，20（2）：插1-插18.
[3] Hayashi PH，Fontana RJ. Clinical features，diagnosis，and natural history of drug-induced liver injury [J]. Semin Liver Dis，2014，34（2）：134-144.
[4] Shen T，Liu Y，Shang J，et al. Incidence and Etiology of Drug-Induced Liver Injury in Mainland China [J]. Gastroenterology，2019，156（8）：2230-2241.
[5] Perreault M，Wunsch E，Bialek A，et al. Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations：Contribution of Hepatic and Renal Glucuronidation Reactions [J]. Can J Gastroenterol Hepatol，2018， 2018：8096314.
[6] 周良辅，毛颖，王任直.中国中枢神经系统胶质瘤诊断与治疗指南（2015）[J].中华医学杂志，2016，96（7）：485-509.
[7] Lu Y，Zhao Z，Wang J，et al. Safety and efficacy of combining capecitabine and temozolomide （CAPTEM） to treat advanced neuroendocrine neoplasms：A meta-analysis [J]. Medicine （Baltimore），2018，97（41）：e12784.
[8] Mason M，Adeyi O，Fung S，et al. Vanishing bile duct syndrome in the context of concurrent temozolomide for glioblastoma [J]. BMJ Case Rep，2014，2014.
[9] Bonkovsky HL，Kleiner DE，Gu J，et al. Clinical presentations and outcomes of bile duct loss caused by drugs and herbal and dietary supplements [J]. Hepatology，2017，65（4）：1267-1277.
[10] 韩骐蔓，侯和磊，张晓春.国产创新药安罗替尼抗肿瘤治疗的研究进展[J].中国新药与临床杂志，2020，39（2）：65-70.
[11] Chin M，Levy RD，Yoshida EM，et al. Sitaxsentan-induced acute severe hepatitis treated with glucocorticoid therapy [J]. Can Respir J，2012，19（1）：e1-e2.
[12] 张玉果，赵素贤，李文聪，等.糖皮质激素治疗重症药物性肝损伤的临床研究[J].肝脏，2017，22（3）：214-218.
[13] 马曾庆，孙鲁宁，吴德芹，等.药物性胆管损伤研究进展[J].中国药业，2020，29（10）：57-60.
[14] Fang S，Qi L，Zhou N，et al. Case report on alimentary tract hemorrhage and liver injury after therapy with oseltamivir：A case report [J]. Medicine （Baltimore），2018， 97（38）：e12497.
[15] Bai Z，Li H，Zheng K，et al. A good response to glucocorticoid for sub-acute liver failure：a case report [J]. Transl Gastroenterol Hepatol，2018，3：25.
[16] Hou FQ，Zeng Z，Wang GQ. Hospital admissions for drug-induced liver injury：clinical features，therapy，and outcomes [J]. Cell Biochem Biophys，2012，64（2）：77-83.
[17] Hu PF，Wang PQ，Chen H，et al. Beneficial effect of corticosteroids for patients with severe drug-induced liver injury [J]. J Dig Dis，2016，17（9）：618-627.
[18] Herishanu Y，Lishner M，Kitay-Cohen Y. The role of glucocorticoids in the treatment of fulminant hepatitis induced by dacarbazine [J]. Anticancer Drugs，2002，13（2）：177-179.
[19] Mcmillin M，Frampton G，Quinn M，et al. Suppression of the HPA Axis During Cholestasis Can Be Attributed to Hypothalamic Bile Acid Signaling [J]. Mol Endocrinol，2015，29（12）：1720-1730.
[20] Kakisaka K，Suzuki Y，Jinnouchi Y，et al. Unfavorable prognosis of patients with acute liver injury due to drug-induced liver injury and acute exacerbation of hepatitis B virus infection [J]. Hepatol Res，2019，49（11）：1286-1293.
[21] van der Geest R，Ouweneel AB，van der Sluis RJ，et al. Endogenous glucocorticoids exacerbate cholestasis-associated liver injury and hypercholesterolemia in mice [J]. Toxicol Appl Pharmacol，2016，306：1-7.
[22] Whittier X，Saag KG. Glucocorticoid-induced Osteoporosis [J]. Rheum Dis Clin North Am，2016，42（1）：177-189.
京公网安备 11010502046598号