Abstract：Objective To explore the prescriptions rule of traditional Chinese medicine in the treatment of lung adenocarcinoma. Methods The medical records of lung adenocarcinoma treated with traditional Chinese medicine were collected by searching CNKI and Wanfang database from January 2010 to November 2020. The group information was extracted and inputed into excel 2013 to establish a database. SPSS 23 and SPSS Modeler 18 were used to mine the efficacy, meridian tropism, association rules and clustering of traditional Chinese medicine. Results There were 96 eligible medical records, involving 193 drugs. They were divided into 13 categories according to their efficacy. The first three categories were used frequently, which were tonic drugs, blood stasis-activating drugs and phlegm-resolving drugs. The medicines entering to lung, spleen, stomach and liver channels were mainly used. The combination of medicines with strong correlation were the heat-clearing and detoxifying medicine plus the tonic medicine, the bloodpromoting medicine. In this way, four major clusters were formed which were commonly used drug combinations including Astragali Radix, Atractylodis Macrocephalae Rhizoma, Hedyotis. Conclusion Traditional Chinese medicine treating lung adenocarcinoma is often based on the basic principle of “treating both the symptoms and the root causes, invigorating qi and removing blood stasis, and harmonizing the five zang organs”, which is combined with Chinese herbs related to supplementing qi and activating blood circulation, eliminating blood stasis and resolving stagnation, strengthening spleen and resolving phlegm.
吴可 李庆伟 郑坤 安丽凤. 基于数据挖掘探析中医治疗肺腺癌用药规律[J]. 中国医药导报, 2021, 18(17): 146-148,156.
WU Ke LI Qingwei ZHENG Kun AN Lifeng. Analysis on medication rule of traditional Chinese medicine in the treatment of lung adenocarcinoma based on data mining. 中国医药导报, 2021, 18(17): 146-148,156.
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