Effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorder patients
CHEN Xiyuan1 WANG Rui2
1.Department of Community Psychiatry, Brain Hospital Affiliated to Guangzhou Medical University, Guangdong Province, Guangzhou 510370, China; 2.Department of Psychology, Liuzhou Workers Hospital, Guangxi Zhuang Autonomous Region, Liuzhou 545005, China
Abstract：Objective To investigate the effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorde patients and its influence on the levels of dopamine (DA), 5-hydroxytryptamine (5-HT) and neuron specific enolase (NSE). Methods From April 2019 to April 2020, 102 cases of adolescent psychological disorder patients in Brain Hospital Affiliated to Guangzhou Medical University were selected as study objects. According to the random number table method, they were divided into observation group (51 cases) and control group (51 cases). Both groups were given psychotherapy, control group was treated with Aripiprazole, while observation group was given Shumian Capsules orally on the basis of control group. The course of treatment was eight weeks. The curative effect of two groups after eight weeks of treatment, the scores of self rating anxiety scale (SAS), self rating depression scale (SDS), Pittsburgh sleep quality index (PSQI), DA, 5-HT before and after treatment and NSE levels and the adverse reactions during the treatment were compared between two groups. Results The total effective rate of observation group was higher than that of control group (P < 0.05). Before treatment, there were no significant differences in SAS and SDS scores between two groups (P > 0.05). After eight weeks of treatment, SAS and SDS scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there was no significant difference in PSQI score between two groups (P > 0.05). After eight weeks of treatment, PSQI scores in both groups were lower than those before treatment, and observation group was lower than control group (P < 0.05). Before treatment, there were no significant differences in serum DA, 5-HT and NSE levels between two groups (P > 0.05). After eight weeks of treatment, the levels of serum DA and 5-HT in both groups were higher than those before treatment, and observation group was higher than control group (P < 0.05); while serum NSE level was lower than that before treatment, and observation group was lower than control group (P < 0.05). No obvious adverse reactions occurred in two groups. Conclusion Shumian Capsules combined with Aripiprazole has a good effect in the treatment of adolescent psychological disorder, which can reduce the psychological disorder, improve the sleep quality, increase the levels of DA and 5-HT, and reduce the level of NSE.
陈夕圆1 王睿2. 舒眠胶囊联合阿立哌唑治疗青少年心理障碍患者的效果[J]. 中国医药导报, 2021, 18(17): 114-117,125.
CHEN Xiyuan1 WANG Rui2. Effect of Shumian Capsules combined with Aripiprazole in the treatment of adolescent psychological disorder patients. 中国医药导报, 2021, 18(17): 114-117,125.
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