Abstract：Objective To investigate information processing speed and working memory and correlation analysis in in-patients with first-diagnosed schizophrenia and chronic schizophrenia. Methods First-diagnosed schizophrenia inpatients in Wuxi Mental Health Center Affiliated to Nanjing Medical University (“our hospital” for short) from February 2012 to June 2015 were selected as the FDS group (24 cases) and chronic schizophrenia inpatients as the CSz group (86 cases). During the same period, 25 healthy people matched with the FDS group were recruited as the HC-F group and 56 healthy people matched with the CSz group were recruited as the HC-C group in our hospital. The Wechsler adult intelligence scale included digit symbol test (Dsy), digit span test-backword (DSp-B), MATRICS consensus cognitive batter included verbal fluency test (VF) and trail making A test (TMA). Partial correlation analysis was used to control for age and education level. Results DSy in the FDS group was lower than that in the HC-F group, while TMA in the FDS group was higher than that in the HC-F group, and the differences were statistically significant (P < 0.05). DSy, verbal fluency test-correct, DSp-B in the CSz group were lower than those in the HC-C group, trail making A test-model (TMA-M), TMA, verbal fluency test-repetition (VF-R) were higher than those in the HC-C group, and the differences were statistically significant (P < 0.05). In the FDS group, trail making A test-error was negatively correlated with onset age (r < 0, P < 0.05), and positively correlated with the course of disease (r > 0, P < 0.05). VF-R in the CSz group was negatively correlated with the score of general pathology scale (r < 0, P < 0.05). TMA-M and TMA were positively correlated with sex (r ＞ 0, P < 0.05). Conclusion First-diagnosed schizophrenia patients have deficiency in information processing speed, while chronic schizophrenia patients have impairment in information processing speed and working memory. It is suggested that clinicians pay more attention to the effect of metabolic diseases on cognitive function with first-diagnosed schizophrenia patients, and pay more attention to the effect of gender on cognitive function with chronic schizophrenia patients.
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