Abstract：Objective To investigate the effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency. Methods A total of 100 patients with vertebro-basilar artery insufficiency admitted to Wuhu Hospital of Traditional Chinese Medicine in Anhui Province from January 2018 to December 2019 were selected and they were divided into observation group and control group according to random number table method, with 50 patients in each group. The control group was treated with Gastrodin on the basis of conventional treatment, and the observation group was treated with Dingxuan Granules on the basis of the control group. Both groups were treated continuously for 14 days. The clinical efficacy after treatment, the changes of blood flow velocities of left vertebral artery (LVA), right vertebral artery (RVA), basilar artery (BA), cerebral blood flow (CBF) in basal ganglia region, cerebral blood volume (CBV), mean transit time (MTT) before and after treatment were compared between the two groups, and the incidence of adverse reactions during treatment were compared between the two groups. Results The total clinical effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The blood flow velocities of LVA, RVA, BA and basal ganglia region CBF and CBV in the two groups were higher than before treatment, and the MTT was shorter than before treatment. The blood flow velocities of LVA, RVA, BA and basal ganglia region CBF and CBV in the observation group were higher than those in the control group, and the MTT was shorter than that in the control group, with statistical significance (all P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency has obvious effect and good safety, which is worthy of application and promotion.
毕梦非 张荣珍 王亚君. 定眩颗粒联合天麻素治疗椎基底动脉供血不足的效果[J]. 中国医药导报, 2021, 18(17): 94-97.
BI Mengfei ZHANG Rongzhen WANG Yajun. Effect of Dingxuan Granules combined with Gastrodin in the treatment of vertebro-basilar artery insufficiency. 中国医药导报, 2021, 18(17): 94-97.
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