Abstract：Objective To explore the action target and potential mechanism of modified Huangqi Chifeng Decoction in treating IgA nephropathy by using network pharmacology knowledge. Methods Related chemical components of seven traditional Chinese medicine in modified Huangqi Chifeng Decoction and their action targets were screened out from the traditional Chinese medicine systems pharmacology database and analysis platform, and the active components of traditional Chinese medicine were screened out according to the corresponding standards. The disease targets related to IgA nephropathy were screened out through online Mendelian inheritance in man and Genecards database, and the common targets of modified Huangqi Chifeng Decoction and disease were calculated by R language. The corresponding regulatory network was plotted and constructed in Cytoscape research software. The String database was used to construct the corresponding protein-protein interaction network. The GO function and KEGG pathway enrichment analysis of the target were performed by R language to identify the possible key targets and key pathways. Results A total of 45 active components and 95 potential action targets were screened out from the modified Huangqi Chifeng Decoction. The treatment of IgA nephropathy may be related to the influence of the expression of albumin, interleukin (IL)-6, serine/threonine kinase 1, vascular endothelial growth factor A, and other genes. A total of 115 enrichment results were included in GO biofunction analysis, mainly involving phosphatase binding, heme binding, cytokine receptor binding and other processes. A total of 151 metabolic pathways were obtained by KEGG enrichment, mainly including AGE-RAGE signaling pathway, IL-17 signaling pathway, tumor necrosis factor signaling pathway, etc. Conclusion Based on the network pharmacology method, it is speculated that the modified Huangqi Chifeng Decoction can be used in the treatment of IgA nephropathy through various interventions, and has the therapeutic advantages of multiple components, multiple targets and multiple pathways, which provides theoretical reference for the future study of its pharmacodynamic substance basis and action mechanism.
马思佳 赵明明 常美莹 余怡 王如梦 张昱. 基于网络药理学方法的加味黄芪赤风汤治疗IgA肾病作用机制的研究[J]. 中国医药导报, 2021, 18(17): 29-35.
MA Sijia ZHAO Mingming CHANG Meiying YU Yi WANG Rumeng ZHANG Yu. Study on the action mechanism of modified Huangqi Chifeng Decoction in the treatment of IgA nephropathy based on network pharmacology method. 中国医药导报, 2021, 18(17): 29-35.
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