糖皮质激素受体基因NR3C1 rs7701443和rs2963156多态性与脑小血管病的相关性分析

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摘要目的探讨糖皮质激素受体基因（NR3C1）rs7701443和rs2963156多态性与脑小血管病（CSVD）的相关性。方法应用一代测序法，选取2013年3月—2018年5月应急总医院门诊及住院部患者，根据头颅MRI诊断有无CSVD分为CSVD组（200例）和对照组（100名），进行NR3C1 rs7701443和rs2963156多态性分布情况分析。结果两组rs7701443基因频率比较，差异无统计学意义（P ＞ 0.05）；排除高血压、冠心病、糖尿病等CSVD危险因素影响后，两组基因型频率比较，差异无统计学意义（P ＞ 0.05）。两组rs2963156基因频率比较，差异无统计学意义（P ＞ 0.05）；排除高血压、冠心病、糖尿病等CSVD危险因素影响后，两组基因型频率比较，差异无统计学意义（P ＞ 0.05）。结论尚不能认为NR3C1的rs7701443和rs2963156的基因多态性与CSVD发病有关。

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	李静雅1
	2 王君1 莫卫焱1 任歆1 汪琦1 周卫东1

关键词 ：糖皮质激素受体基因, 基因多态性, 脑小血管病, 危险因素, 相关性

Abstract：Objective To explore the correlation between the glucocorticoid receptor gene (NR3C1) rs7701443 and rs2963156 polymorphisms and cerebral small vessel disease (CSVD). Methods Using the first-generation sequencing method, patients from the outpatient and inpatient of the Emergency General Hospital from March 2013 to May 2018 were selected and divided into the CSVD group (200 patients) and the control group (100 patients) based on the presence or absence of CSVD diagnosed by cranial MRI. The distribution of NR3C1 rs7701443 and rs2963156 polymorphisms were analyzed. Results There was no statistically significant difference in the frequency of rs7701443 between the two groups (P ＞ 0.05); after excluding the influence of CSVD risk factors such as hypertension, coronary heart disease and diabetes, the difference in the frequency of genotypes between the two groups was not statistically significant (P ＞ 0.05). There was no statistically significant difference in the frequency of rs2963156 between the two groups (P ＞ 0.05); after excluding the influence of CSVD risk factors such as hypertension, coronary heart disease, diabetes, etc., the difference in the frequency of genotypes between the two groups was not statistically significant (P ＞ 0.05). Conclusion The polymorphisms of rs7701443 and rs2963156 of NR3C1 may not be related to the onset of CSVD.

Key words： Glucocorticoid receptor gene Single nucleotide polymorphism Cerebral small vessel disease Risk factors Correlation

基金资助:首都卫生发展科研专项资助项目（首发2011-6011-01）；
应急总医院医学发展科研基金项目（201513）。

通讯作者: 周卫东（1968-），男，主任医师；研究方向：脑小血管病与认知障碍。

作者简介: 李静雅（1990-），女，硕士；研究方向：脑小血管病与认知障碍。

引用本文:

李静雅1,2 王君1 莫卫焱1 任歆1 汪琦1 周卫东1. 糖皮质激素受体基因NR3C1 rs7701443和rs2963156多态性与脑小血管病的相关性分析[J]. 中国医药导报, 2021, 18(16): 42-45.
LI Jingya1,2 WANG Jun1 MO Weiyan1 REN Xin1 WANG Qi1 ZHOU Weidong1. Correlation analysis between glucocorticoid receptor gene NR3C1 rs7701443, rs2963156 polymorphisms and cerebral small vessel disease. 中国医药导报, 2021, 18(16): 42-45.

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https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I16/42

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