Abstract：Objective To analyze the colonization and antimicrobial susceptibility of Group B Streptococcus (GBS) in the third trimester of pregnancy and its pregnancy outcome. Methods The medical records of 500 pregnant women who voluntarily underwent vaginal combined rectal GBS screening in the Second Affiliated Hospital of Anhui Medical University from January to September 2020 were retrospectively analyzed. The colonization of GBS and the antimicrobial susceptibility of GBS positive samples were analyzed. According to the results of GBS screening, they were divided into GBS negative group and GBS positive group, and the pregnancy outcome of two groups was compared. Results A total of 56 pregnant women with GBS positive were detected among 500 pregnant women, and the colonization rate was 11.20%; among which 41 were positive vaginal specimens, the colonization rate was 8.20%; there were 32 positive rectal specimens, the colonization rate was 6.40%. GBS had high resistance to Clindamycin, Erythromycin and Tetracycline, and high sensitivity to Cefuroxime, Linezolid, Vancomycin, Ampicillin and Penicillin. The proportion of prenatal fever, abnormal pregnancy history of GBS positive group were higher than those of GBS negative group, and the differences were statistically significant (all P < 0.05). The proportions of premature rupture of membranes, puerperium infection, postpartum hemorrhage, neonatal septicemia and neonatal pneumonia in GBS positive group were higher than those in GBS negative group, and the differences were statistically significant (all P < 0.05). Conclusion The overall colonization rate of GBS is low in the third trimester of pregnancy, and the detection rate of GBS can be increased by comprehensive rectal examination. GBS positive patients have higher adverse pregnancy outcomes such as premature rupture of membranes, puerperal infection, Prenatal fever postpartum hemorrhage, neonatal septicemia, and neonatal pneumonia. GBS has high sensitivity to Cefuroxime, Linezolid, Vancomycin, Ampicillin and Penicillin.
宋玉荣 詹磊 孙莉. 妊娠晚期B群链球菌定植情况、抗菌药物敏感性及妊娠结局分析[J]. 中国医药导报, 2021, 18(15): 113-116.
SONG Yurong ZHAN Lei SUN Li. Analysis of colonization of Group B Streptococcus, antimicrobial susceptibility and pregnancy outcome in the third trimester of pregnancy. 中国医药导报, 2021, 18(15): 113-116.
[1] Furfaro LL，Nathan EA，Chang BJ，et al. Group B streptococcus prevalence，serotype distribution and colonization dynamics in Western Australian pregnant women [J]. J Med Microbiol，2019，68（5）：728-740.
[2] Russell NJ，Seale AC，O’Driscoll M，et al. Maternal Colonization With Group B Streptococcus and Serotype Distribution Worldwide：Systematic Review and Meta-analyses [J]. Clin Infect Dis，2017，65（suppl_2）：S100-S111.
[3] 李之珩，陈文诗，官建泳，等.澳门地区孕妇B群链球菌筛查和新生儿早发型感染分析[J].临床检验杂志，2019， 37（4）：314-316.
[4] 杨训俊，丁红香，倪莉.围产期孕妇生殖道B群链球菌感染临床特征[J].温州医科大学学报，2019，49（12）：914-917.
[5] Virranniemi M，Raudaskoski T，Haapsamo M，et al. The effect of screening-to-labor interval on the sensitivity of late-pregnancy culture in the prediction of group B streptococcus colonization at labor：A prospective multicenter cohort study [J]. Acta Obstet Gynecol Scand，2019，98（4）：494-499.
[6] 王广荣.B族链球菌感染对妊娠结局的影响[J].中国现代医药杂志，2020，22（11）：50-52.
[7] Verani JR，McGee L，Schrag SJ，et al. Prevention of perinatal group B streptococcal disease--revised guidelines from CDC，2010 [J]. MMWR Recomm Rep，2010，59（RR-10）：1-36.
[8] Clinical and Laboratory Standards Institute. M100-S22 Performance standards for antimicrobial susceptibility testing; twenty-second informational supplement [S]. Wayne，PA：Clinical and Laboratory Standards Institute，2012.
[9] Heath PT，Culley FJ，Jones CE，et al. Group B streptococcus and respiratory syncytial virus immunisation during pregnancy：a landscape analysis [J]. Lancet Infect Dis，2017，17（7）：e223-e234.
[10] Gopal Rao G，Hiles S，Bassett P，et al. Differential rates of group B streptococcus（GBS） colonisation in pregnant women in a racially diverse area of London，UK：a cross-sectional study [J]. BJOG，2019，126（11）：1347-1353.
[11] 聂署萍，成子贤，王琼，等.深圳地区孕妇定植型B群链球菌流行病学特征[J].中国感染控制杂志，2018，17（6）：522-526.
[12] 纪银慧.孕妇B族链球菌感染对母婴结局的影响[J].中国实用医刊，2019，46（21）：89-91.
[13] 钱耀先，陈俊，王燕，等.孕妇B群链球菌携带情况及对新生儿结局的影响[J].检验医学与临床，2019，16（14）：1969-1971，1975.
[14] 陆少颜，徐烨，陈泳言，等.分娩时抗生素预防性治疗后新生儿B族链球菌感染情况分析[J].中国妇幼保健，2017， 32（6）：1205-1206.
[15] 普筱敏，张力，旷凌寒，等.成都地区妊娠晚期B群链球菌定植情况调查及围产结局分析[J].现代妇产科进展，2018，27（1）：33-36.
[16] 陈慧慧，范建霞，陆庭嫣，等.孕妇B族溶血性链球菌感染对母婴的影响[J].上海医学，2009，32（2）：128-130.
[17] 胡矩锋.孕晚期B群链球菌对母婴围产结局的影响[J].中国社区医师，2020，36（11）：15-16，18.
[18] 王静，刘杰，王淑贞，等.徐州地区妊娠晚期妇女感染B群链球菌的筛检情况及药物敏感性分析[J].国际检验医学杂志，2015，36（20）：2963-2964，2966.
[19] Dai W，Zhang Y，Xu Y，et al. The effect of group B streptococcus on maternal and infants’ prognosis in Guizhou，China [J]. Biosci Rep，2019，39（12）：BSR20191575.
[20] 原锦华，焦莹莹，王娇，等.妊娠晚期阴道B族链球菌的感染对肠道菌群和妊娠结局的影响[J].中国微生态学杂志，2020，32（3）：330-333.
[21] 张倩，严涵，张凤，等.妊娠晚期生殖道B族溶血性链球菌（GBS）感染及对妊娠结局的影响分析[J].河北医学，2018，24（4）：608-612.
[22] 陈军，荆成宝.妊娠晚期孕妇B族链球菌带菌情况对母婴结局的影响及耐药性监测[J].实用预防医学，2018， 25（10）：1264-1266.
[23] 张月辉，郑建琼，王叶平，等.生殖道B族链球菌定植与早产的相关性研究[J].中国现代医生，2019，57（35）：65-68.
[24] 黄薇.预防性使用抗生素治疗对B族链球菌阳性孕妇围生儿结局的影响[J].中国当代医药，2021，28（8）：96-98.
[25] 张萍萍，孙素玉，沈旭娜，等.妊娠晚期B族链球菌感染孕妇阴道微生物菌群分析[J].中国计划生育学杂志，2020，28（2）：226-228，232.
[26] 杨林东，包芳，吴元赭，等.晚期妊娠孕妇B群链球菌定植状况及妊娠结局分析[J].浙江大学学报：医学版，2020， 49（3）：389-396.
[27] 蒋玉，潘珂，尚志容，等.妊娠晚期女性B族链球菌感染状态与阴道微生态及妊娠结局的相关性分析[J].中国病案，2020，21（3）：103-107.
京公网安备 11010502046598号