Abstract：Objective To analyze the clinical characteristics of pyogenic liver abscess (PLA) patients with diabetes mellitus in order to guide the clinical diagnosis and treatment. Methods A total of 225 patients with PLA treated in the First Affiliated Hospital of Chongqing Medical University from January 2015 to December 2019 were selected, they were divided into diabetic group (109 cases) and non-diabetic group (116 cases) according to whether they had diabetes or not. The general data, basic diseases, clinical manifestation, laboratory findings, pathogenic results, complications, treatment and prognosis of the two groups were analyzed retrospectively. Results The mean age of diabetic group was higher than that of non-diabetic group (P ＜ 0.05). The probability of hypertension and cerebral infarction in diabetic group was higher than that in non-diabetic group (P ＜ 0.05). The probability of fever and fatigue in diabetic group was higher than that in non-diabetic group (P ＜ 0.05), and the prealbumin level was lower than that in non-diabetic group (P ＜ 0.05). Abdominal distension, abdominal pain, vomiting, chills and abdominal tenderness, tap pain, white blood cell count, liver area percentage granulocyte, hemoglobin, platelet count, albumin, alanine aminotransferase, aspartate aminotransferase, total bilirubin, activated clotting time live enzymes, prothrombin time, blood urea nitrogen, serum creatinine, calcitonin original differences between groups were no statistical significance (all P ＞ 0.05). The infection rate of total negative bacteria and Klebsiella Pneumoniae (KP) in diabetic group was higher than that in non-diabetic group, and the infection rate of streptococcus mueller group was lower than that in non-diabetic group (P ＜ 0.05). The proportion of pneumonia, sepsis and septic shock in DM group was higher than that in non-diabetic group (P ＜ 0.05), and there was no significant difference in antibiotic use and prognosis between the two groups (P ＞ 0.05). Conclusion PLA complicated with diabetes is common in middle-aged and elderly men with atypical clinical manifestations, easy to be complicated with KP infection, and more prone to complications such as pneumonia, sepsis, septic shock.
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