Study on correlation between generalized anxiety disorder and thyroid hormone level
YANG Zhihui1 PEI Qinghua2 LU Meimei1 WANG Chenxi1
1.The Third School of Clinical Medicine of Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Encephalopathy, the Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China
Abstract：Objective To investigate the relationship and correlation between generalized anxiety disorder (GAD) and thyroid hormone level. Methods With the cross-sectional study method, a total of 62 patients with generalized anxiety disorder who visited the Department of Encephalopathy of the Third Affiliated Hospital of Beijing University of Chinese Medicine (“our hospital” for short) from June 2019 to January 2020 were selected as study group, a total of 60 healthy adults who take a physical examination in the physical examination center of our hospital during the same period were selected as the control group. Serum thyroid hormone levels were measured in all subjects, including thyroid stimulating hormone (TSH), triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4) and free thyroxine (FT4). Hamilton anxiety scale (HAMA) was used to evaluate the anxiety level of all members of the study group, there were 20 cases in the mild anxiety group, 32 cases in the moderate anxiety group and 10 cases in the severe anxiety group. The differences of thyroid hormone levels between the study group and the control group and among the groups with different degrees of generalized anxiety disorder were compared. The relationship between generalized anxiety disorder and thyroid hormone levels was analyzed, the correlation between the groups with different degrees of generalized anxiety disorder and thyroid hormone levels was explored. Results The levels of T3 and T4 in the study group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). There were no significant differences in FT3, TSH and FT4 levels between the two groups (P ＞ 0.05). There were significant differences in T4 level among groups with different anxiety levels (P ＜ 0.05), and T4 level in severe anxiety group was higher than that in mild anxiety group and moderate anxiety group, respectively, with statistical significance (P ＞ 0.05). There were no significant differences in TSH, T3, FT3 and FT4 levels among the three groups (P ＞ 0.05). The anxiety level of GAD patients was positively correlated with T4 level (r = 0.332, P ＜ 0.01), and had no significant correlation with FT3, TSH, T3 and FT4. Conclusion Patients with GAD have abnormal thyroid hormone level, that is abnormal thyroid hormone level is correlated with the occurrence of GAD to a certain extent. Reasonable regulation of thyroid hormone level can reduce the risk of GAD to a certain extent.
杨志慧1 裴清华2 卢美枚1 王晨曦1. 广泛性焦虑障碍与甲状腺激素水平的相关性研究[J]. 中国医药导报, 2021, 18(14): 119-122.
YANG Zhihui1 PEI Qinghua2 LU Meimei1 WANG Chenxi1. Study on correlation between generalized anxiety disorder and thyroid hormone level. 中国医药导报, 2021, 18(14): 119-122.
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