Detection of serum interleukin and immunoglobulin levels in patients with esophageal cancer and its clinical significance
LI Rizhu1 GAO Jie2 NONG Feng1 WANG Juping2 TANG Renguang3
1.Department of Cardiothoracic Vascular Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China;
2.Pathophysiology Teaching and Research Section, Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China; 3.Department of Blood Transfusion, Youjiang Medical University for Nationalities, Guangxi Zhuang Autonomous Region, Baise 533000, China
Abstract：Objective To investigate the expression levels of serum interleukin (IL) and immunoglobulin in patients with esophageal cancer and its clinical significance. Methods A total of 150 patients with esophageal cancer admitted to Affiliated Hospital of Youjiang Medical University for Nationalities (hereinafter referred to as “our hospital”) from January 2016 to December 2018 were selected as esophageal cancer group. A total of 130 healthy subjects were selected as control group as the same period. The expression levels of IL-6, IL-10, IL-18, IgG, IgA and IgM were compared between two groups. At the same time, the expression levels of IL-6, IL-10, IL-18, IgG, IgA and IgM in esophageal cancer patients with different stages and metastasis or non-metastatic were compared. Results The levels of IL-6, IL-18 and IgA in esophageal cancer group were higher than those in control group, and the level of IL-10 was lower than that in control group (all P < 0.05). There were no significant differences in IgG and IgM levels between the two groups (P > 0.05). The levels of IL-6, IL-18 and IgA in stage Ⅲ-Ⅳ group were higher than those in stage Ⅰ-Ⅱ group, and the level of IL-10 was lower than that in stage Ⅰ-Ⅱ group (all P < 0.05). The levels of IL-6, IL-18 and IgA in metastatic esophageal cancer group were higher than those in non-metastatic esophageal cancer group, and the level of IL-10 was lower than that in non-metastatic esophageal cancer group (all P < 0.05). Conclusion The levels of IL-6, IL-18 and IgA in patients with esophageal cancer, stage Ⅲ-Ⅳ and metastasis are significantly increased, while IL-10 is significantly decreased. These indexes may provide basis for the diagnosis, treatment and prognosis of esophageal cancer.
李日著1 高洁2 农峰1 王居平2 唐任光3. 食管癌患者血清白细胞介素和免疫球蛋白水平检测及其临床意义[J]. 中国医药导报, 2021, 18(14): 89-92,110.
LI Rizhu1 GAO Jie2 NONG Feng1 WANG Juping2 TANG Renguang3. Detection of serum interleukin and immunoglobulin levels in patients with esophageal cancer and its clinical significance. 中国医药导报, 2021, 18(14): 89-92,110.
[1] 喻傲，焦子宸，王涛.食管癌术后管状胃功能研究及应用进展[J].中国胸心血管外科临床杂志，2019，26（10）：1032-1037．
[2] 薛金良，靳超，张晓.微创食管癌根治术治疗对食管癌患者的临床疗效、生存率及并发症的影响分析[J].四川解剖学杂志，2020，28（4）：97-98.
[3] Dermine S，Lévi-Strauss T，Abou Ali E，et al. Organ Preservation after Endoscopic Resection of Early Esophageal Cancer with a High Risk of Lymph Node Involvement [J]. Cancers（Basel），2020，12（12）：E3598.
[4] 李国良，朱明闯，熊鹏，等.长链非编码RNA在食管癌中的研究进展[J].实用医学杂志，2018，34（24）：4015-4018.
[5] Chen H，Luo J，Guo J. Construction and Validation of a 7-Immune Gene Model for Prognostic Assessment of Esophageal Carcinoma [J]. Med Sci Monit，2020，26：e927392.
[6] Chen H，Zhou X，Tang X，et al. Prediction of Lymph Node Metastasis in Superficial Esophageal Cancer Using a Pattern Recognition Neural Network [J]. Cancer Manag Res，2020，12：12249-12258.
[7] Lin W. The impact of hot fluid food on esophageal squamous cell carcinoma might be underestimated [J]. Eur J Cancer Prev，2021，30（1）：120-121.
[8] Müller DT，Babic B，Herbst V，et al. Does Circular Stapler Size in Surgical Management of Esophageal Cancer Affect Anastomotic Leak Rate? 4-Year Experience of a European High-Volume Center [J]. Cancers（Basel），2020，12（11）：3474.
[9] Ziaja D，Stasiów B，Sznapka M，et al. Adaptation of endovascular technique of self-expandable metal esophageal stent implantation in palliative treatment of malignant dysphagia in the course of esophageal and bronchial cancers：A one-center study [J]. Adv Clin Exp Med，2020，29（11）：1363-1366.
[10] 陈宏明，李日著，唐任光，等.食管癌患者血清白细胞介素和急性时相反应蛋白水平及其临床意义[J].广西医学，2016，38（7）：929-931.
[11] 李浩淼，孙海波，郑燕，等.AJCC/UICC第八版食管及食管胃交界部癌TNM分期解读及中文版主要内容[J].中国胸心血管外科临床杂志，2017，24（2）：87-92.
[12] Matsuura K，Osaki A，Ichinose Y，et al. Patient with Recurrent Breast Cancer Who Developed Radiation Esophagitis with Severe Esophageal Stenosis after Combined Bevacizumab and Paclitaxel Therapy-A Case Report [J]. Gan To Kagaku Ryoho，2020，47（11）：1605-1608.
[13] Hino K，Kajiwara T，Nishina T，et al. Tolerability of Definitive Chemoradi-otherapy in Elderly Patients with Eso-phageal Cancer [J]. Gan To Kagaku Ryoho，2020，47（11）：1577-1581.
[14] Takeuchi M，Onoda M，Yoshida K，et al. Effect of Venous Superdrainage on Colon Interposition for Esophageal Reconstruction [J]. J UOEH，2020，42（4）：331-334.
[15] ?覵ukaszewicz-Zaj?諭c M，Mroczko B，Kozlowski M，et al. Higher impor-tance of interleukin 6 than classic tumor markers（carcinoembryonic an-tigen and squamous cell cancer antigen）in the diagnosis of esophageal cancer patients [J]. Dis Esophagus，2012，25（3）：242-249．
[16] Neurath MF，Finotto S. IL-6 signaling in autoimmunity chronic in flamm-ation and inflammation-associated cancer [J]. Cytokine Growth Factor Rev，2011，22（2）：83-89．
[17] Tanaka T，Narazaki M，Kishimoto T. Interleukin（IL-6）Immunotherapy [J]. Cold Spring Harb Perspect Biol，2018，10（8）：a028456.
[18] Wang X，Wong K，Ouyang W，et al. Targeting IL-10 Family Cytokines for the Treatment of Human Diseases [J]. Cold Spring Harb Perspect Biol，2019，11（2）：a028548.
[19] Crena J，Subramanian S，Victor DJ，et al． Single nucleotide polymorphism at-1087 locus of interleukin-10 gene promoter is associated with severechronic periodontitis in nonsmoking patients [J]. Eur J Dent，2015，9（3）：387-393.
[20] Huang AX，Lu LW，Liu WJ，et al． Plasma inflammatory cytokine IL-4，IL-8，IL-10，and TNF-α levels correlate with pulmonary function in patients with Asthma-Chronic Obstructive Pulmonary Disease （COPD） overlap syndrome [J]. Med Sci Monit，2016，22：2800-2808.
[21] Yasuda K，Nakanishi K，Tsutsui H. Interleukin-18 in Health and Disease [J]. Int J Mol Sci，2019，20（3）：649.
[22] Wang M，Zhu XY，Wang L，et al. The -607C/A polymorphisms in Interleukin-18 gene promoter contributes to cancer risk：evidence from a meta-analysis of 22 case-control studies [J]. PLoS One，2013，8（10）：e76915.
[23] 王记红.IgA在食管上皮内瘤变组织及癌中的表达[D].汕头：汕头大学，2011.
[24] Xu ML，Kim HJ，Kim SC，et al. Serum anti-GAPDH autoantibody levels reflect the severity of cervical lesions: A potential serum biomarker for cervical cancer screening [J]. Oncology letters，2019，18（1）：255-264.
[25] Zheng H，Li M，Ren W，et al. Expression and secretion of immunoglobulin alpha heavy chain with diverse VDJ recombinations by human epithelial cancer cells [J]. Mol Immunol，2007，44（9）：2221-2227.
[26] 林圣程.食道癌患者不同术式围手术期IgG、IgM、IgA及T细胞亚群的水平变化分析[D].昆明：昆明医科大学，2017.
[27] Gao SG，Yang JQ，Ma ZK，et al. Preoperative serum immunoglobulin G and A antibodies to porphyromonas gingivalis are potential serum biomarkers for the diagnosis and prognosis of esophageal squamous cell carcinoma [J]. BMC Cancer，2018，18（1）：17.
[28] 林勇龙，赖奕静，廖泽飞，等.食管癌患者血清结合珠蛋白水平的检测及临床意义[J].现代肿瘤医学，2021，29（1）：49-51.
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