Abstract：Diabetic nephropathy (DN) is a common and serious microvascular complication of diabetes mellitus, and it is the leading cause of end-stage renal disease (ESRD). Despite the use of various drugs such as renin-angiotensin system inhibitors, DN often continues to progress, and patients are at great risk of progressing to ESRD. Sodium-glucose cotransporter 2 inhibitors (SGLT-2i) are a novel class of target drugs that have been extensively investigated in type 2 diabetes mellitus (T2DM). The inhibitors block sodium and glucose reabsorption in the renal proximal tubule, leading to glycosuria for the treatment of hyperglycemia. Recent large scale clinical trials in T2DM patients have shown that SGLT-2i exhibit cardiorenal protective propertiesin in addition to its hypoglycemic effects. Especially in the patients complicated with DN, SGLT-2i are found to protect renal function and reduce urinary albumin excretion through various mechanisms. Therefore, the latest studies have discovered that SGLT-2i can significantly improve the prognosis of patients with DN. This article reviews the recent progress on SGLT-2i for renal protective effects and mechanisms in DN.
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