血小板活化因子与慢性自发性荨麻疹关系的研究进展
李梦丽1 郭建辉1,2 赵娜1,2 郭雯1,2 宫克1 王 芳1 杜凯晴1 张曼1
1.河北中医学院中医外科学教研室,河北石家庄 050091;
2.河北省沧州中西医结合医院皮肤科,河北沧州 061001
Research progress on relationship between platelet activating factor and chronic spontaneous urticaria
LI Mengli1 GUO Jianhui1,2 ZHAO Na1,2 GUO Wen1,2 GONG Ke1 WANG Fang1 DU Kaiqing1 ZHANG Man1
1.Department of Traditional Chinese Medicine Surgery, Hebei College of Traditional Chinese Medicine, Hebei Province, Shijiazhuang 050091, China; 2.Department of Dermatology, Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine, Hebei Province, Cangzhou 061001, China
摘要 慢性自发性荨麻疹属慢性荨麻疹中的一种特殊类型,多认为肥大细胞紊乱以及嗜碱粒细胞活化和脱颗粒是该过程的中心。发病过程中刺激释放出与变态反应有关的血小板活化因子,另外血小板活化因子是能引起严重变态反应非常重要的致病性成分,还可以激活肥大细胞加重炎症反应,在本研究领域中逐渐引起关注。本文将目前血小板活化因子与慢性自发性荨麻疹关系的研究加以整理,为有效防治慢性自发性荨麻疹提供新方向。
关键词 :
血小板活化因子 ,
慢性自发性荨麻疹 ,
炎症反应 ,
研究进展
Abstract :Chronic spontaneous urticaria is a special type of chronic urticaria. Mast cell disorder and basophil activation and degranulation are considered to be the center of this process. In the course of pathogenesis, it stimulates the release of platelet activating factors related to allergic inflammation. In addition, platelet activating factor is a very important pathogenic component that can cause severe allergic reactions. It can also activate mast cells and aggravate inflammatory reactions, which has gradually attracted attention in this research field. In this paper, the current research on the relationship between platelet activating factor and chronic spontaneous urticaria will be sorted out to provide a new direction for the effective prevention and treatment of chronic spontaneous urticaria.
Key words :
Platelet activating factor
Chronic spontaneous urticaria
Inflammatory reaction
Research progress
基金资助: 河北省中医药管理局中医药类科研计划课题(2020461)。
通讯作者:
郭雯(1980.11-),女,硕士,副主任医师;研究方向:中医药防治皮肤病。
作者简介 : 李梦丽(1994.4-),女,河北中医学院2018级中医外科学专业在读硕士研究生;研究方向:中医药防治皮肤病。
引用本文:
李梦丽1 郭建辉1,2 赵娜1,2 郭雯1,2 宫克1 王 芳1 杜凯晴1 张曼1. 血小板活化因子与慢性自发性荨麻疹关系的研究进展[J]. 中国医药导报, 2021, 18(13): 39-42.
LI Mengli1 GUO Jianhui1,2 ZHAO Na1,2 GUO Wen1,2 GONG Ke1 WANG Fang1 DU Kaiqing1 ZHANG Man1. Research progress on relationship between platelet activating factor and chronic spontaneous urticaria. 中国医药导报, 2021, 18(13): 39-42.
链接本文:
https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I13/39
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