Abstract：Objective To explore the occurrence and clinical characteristics of serious adverse drug reactions (ADRs) of the digestive system caused by Erlotinib, and to provide references for clinical rational use of drugs. Methods The literature on ADRs of the digestive system caused by Erlotinib contained in the Chinese national knowledge infrastructure (CNKI), VIP, PubMed, Medline, and Web of Science from the establishment of the database to January 2020 were searched, while they were performed statistical analysis. Results There were 25 cases of severe ADRs in the digestive system caused by Erlotinib; the age distribution was 51 to 80 years old (20 cases, 80%); most of them occur within 8 weeks after medication (19 cases, 76%); it was more common with gastrointestinal perforation (24%), drug-induced liver injury (52%), and new serious ADRs such as reflex reminiscence gastritis. Conclusion Clinicians and pharmacists need to strengthen their understanding and monitoring of severe ADRs in the digestive system caused by Erlotinib, and carefully evaluate the treatment risks of re-dose to ensure safe and effective clinical use.
周冉 方玉婷 苏丹 李民 沈爱宗. 厄洛替尼致消化系统严重不良反应文献分析[J]. 中国医药导报, 2021, 18(12): 150-153.
ZHOU Ran FANG Yuting SU Dan LI Min SHEN Aizong. Literature analysis on severe adverse drug reactions of digestive system by Erlotinib. 中国医药导报, 2021, 18(12): 150-153.
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