手术切除联合角膜缘干细胞移植治疗翼状胬肉的效果及对泪膜和视觉功能的影响

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摘要目的探讨手术切除联合角膜缘干细胞移植治疗翼状胬肉的效果及对泪膜和视觉功能的影响。方法选取2017年6月—2020年4月在安徽省芜湖市第二人民医院眼科接受治疗的64例翼状胬肉患者为研究对象，采用随机数字表法将其分为对照组和观察组，每组各32例。对照组采用手术切除治疗，观察组采用手术切除联合角膜缘干细胞移植治疗。比较两组临床疗效、泪膜破裂时间（BUT）、基础泪液分泌试验（SIT）、裸眼视力、角膜水平曲度、角膜垂直曲度和散光度。结果观察组总有效率高于对照组，差异有统计学意义（P ＜ 0.05）。治疗后，观察组BUT、SIT、裸眼视力、角膜水平曲度、角膜垂直曲度大于对照组，而散光度小于对照组，差异均有统计学意义（均P ＜ 0.05）。结论手术切除联合角膜缘干细胞移植治疗翼状胬肉效果确切，可改善泪膜和视觉功能。

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	李珊裴蓓孙阿利姜茂华

关键词 ：翼状胬肉, 手术切除, 角膜缘干细胞移植, 泪膜功能, 视觉功能

Abstract：Objective To investigate the effect of surgical excision combined with limbal stem cell transplantation in the treatment of pterygium and its effect on tear film and visual function. Methods A total of 64 patients with pterygium treated in the Department of Ophthalmology, Wuhu Second People’s Hospital, Anhui Province from June 2017 to April 2020 were selected as the research subjects. They were divided into control group and observation group by random number table method, with 32 cases in each group. The control group was treated with surgical excision, and the observation group was treated with surgical excision combined with limbal stem cell transplantation. Clinical efficacy, breakup time of tear film (BUT), schirmer I test (SIT), naked eye vision, corneal horizontal curvature, corneal vertical curvature and astigmatism were compared between the two groups. Results The total effective rate of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). After treatment, BUT, SIT, naked eye vision, corneal horizontal curvature and corneal vertical curvature in the observation group were higher than those in the control group, while astigmatism was lower than those in the control group, the differences were statistically significant (all P ＜ 0.05). Conclusion Surgical excision combined with limbal stem cell transplantation is effective in the treatment of pterygium and can improve tear film and visual function.

Key words： Pterygium Surgical excision Limbal stem cell transplantation Tear film function Visual function

基金资助:国家自然科学基金资助项目（81400407）。

通讯作者: 姜茂华（1969.9-），男，主任医师；研究方向：白内障及青光眼。

引用本文:

李珊裴蓓孙阿利姜茂华. 手术切除联合角膜缘干细胞移植治疗翼状胬肉的效果及对泪膜和视觉功能的影响[J]. 中国医药导报, 2021, 18(12): 138-141.
LI Shan PEI Bei SUN Ali JIANG Maohua. Effect of surgical excision combined with limbal stem cell transplantation in the treatment of pterygium and its effect on tear film and visual function. 中国医药导报, 2021, 18(12): 138-141.

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