Research progress of the relationship between intestinal flora and cardiovascular disease
DOU Wenting1 LI Xiaohui2
1.Teaching Hospital of Capital Institute of Pediatrics, Peking University, Beijing 100020, China;
2.Department of Cardiovascular Medicine, Children’s Hospital, Capital Institute of Pediatrics, Beijing 100020, China
Abstract：Trimethylamine-N-oxide (TMAO), a metabolite of intestinal flora, promotes the occurrence and development of atherosclerosis through the activation of PKC/NF-κB pathway or stimulating foam cell formation. Elevated plasma TMAO can be used as a risk stratification index of poor prognosis in patients with heart failure. Short chain fatty acids, the metabolites of intestinal flora, affect the blood pressure level of host by binding to G-protein-coupled receptors. Meanwhile, intestinal flora can regulate blood pressure by affecting sympathetic nervous, which is the hypothesis of “brain-gut-bone marrow axis”. The abundance and structure of intestinal flora in children with Kawasaki disease have changed. Some special bacteria in the intestine have superantigen activity and can produce heat shock protein. These factors may involve in the occurrence and development of Kawasaki disease by affecting the release of inflammatory factors.
豆文婷1 李晓惠2. 肠道菌群与心血管疾病关系的研究进展[J]. 中国医药导报, 2021, 18(12): 53-56.
DOU Wenting1 LI Xiaohui2. Research progress of the relationship between intestinal flora and cardiovascular disease. 中国医药导报, 2021, 18(12): 53-56.
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