Relationship between PON1 Q192R gene polymorphism and recurrence of cerebral infarction patients treated with Clopidogrel
SHI Rui1 LU Shan1 WANG Wei1 XU Yunfan2 ZHANG Yi3 XIE Zekang1 TIAN Qingyun1 ZHAO Kexin1
1.Department of Pharmacy, Hebei Petrochina Central Hospital, Hebei Province, Langfang 065000, China;
2.CSPC Pharmaceutical Group Limited, Hebei Province, Shijiazhuang 050000, China;
3.Department of Pharmacy, the First Affiliated Hospital of Hebei North University, Hebei Province, Zhangjiakou 075000, China
Abstract：Objective To study the relationship between PON1 gene polymorphism and recurrence of cerebral infarction patients treated with Clopidogrel. Methods A total of 205 patients with cerebral infarction who received Clopidogrel treatment in Hebei Petrochina Central Hospital from October 2012 to March 2019 were selected, according to the inclusion and exclusion criteria, 169 patients were finally included as the study subjects. Situ hybridization was used to detect PON1 Q192R and CYP2C19 genes. Patients without gene mutation were included in QQ group (61 cases), and patients with gene mutation were included in QR+RR group (108 cases). The relative risk was calculated and the correlation between PON1 Q192R gene and recurrence of cerebral infarction patients was analyzed. Results There were no significant differences in the recurrence rate of cerebral infarction at 90 d and 1 year between two groups (P ＞ 0.05). Under the same CYP2C19 genotype background, there were no significant differences in the recurrence rate of cerebral infarction in 90 d and 1 year between two groups (P > 0.05). The relative risk of recurrence of cerebral infarction in QR+RR group was 1.2, 1.3 at 90 d and 1 year, respectively. PON1 Q192R gene was weakly correlated with the reate of recurrence of cerebral infarction. Conclusion PON1 Q192R gene polymorphism may be a genetic susceptibility factor for recurrence of cerebral infarction patients at 90 d and 1 year.
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