Study on correlation of serum trimethylamine oxide and coronary heart disease
LOU Huankun1 ZHAO Ling2 WANG Yilian1 SUN Liming1
1.Department of Cardiovascular Medicine, the Second People’s Hospital of Lianyungang Affiliated to Bengbu Medical College, Jiangsu Province, Lianyungang 222006, China;
2.Clinical Laboratory, the Second People’s Hospital of Lianyungang Affiliated to Bengbu Medical College, Jiangsu Province, Lianyungang 222006, China
Abstract：Objective To study the correl ation of serum trimethylamine oxide (TMAO) and the occurrence of coronary heart disease (CHD). Methods A total of 98 patients with CHD hospitalized in the Department of Cardiovascular Medicine, the Second People’s Hospital of Lianyungang Affiliated to Bengbu Medical College (hereinafter referred to “our hospital”) from July 2019 to June 2020 were selected as the CHD group and 104 healthy volunteers at the same period in our hospital were selected as the control group. Serum TMAO in the two groups were detected by enzymatic linked reaction adsorption assay. The general data and serum TMAO level of the two groups were compared. Multivariate logistic regression was used to analyze the risk factors of CHD, and Spearman correlation coefficient was used to analyze the correlation between serum TMAO level and the severity of CHD. Results The number of male, body mass index (BMI), smoking proportion, serum TMAO, blood glucose, hyperlipidemia and hypertension proportion in the CHD group were significantly higher than those in the control group, with statistical significance (all P ＜ 0.05). Multivariate logistic regression analysis showed that high TMAO level, high BMI, high blood glucose level, complicated with hyperlipidemia, smoking history, complicated with hypertension and high uric acid level were all risk factors for CHD (OR ＞ 1, P ＜ 0.05). Spearman correlation coefficient showed that TMAO was positively correlated with CHD severity (rs = 0.443, P ＜ 0.05). Conclusion The serum TMAO level is higher in patients with CHD, which has a certain correlation with the occurrence of CHD.
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