Effect of Xintongtai Granules in treatment of stable angina pectoris with syndrome of qi stagnation and blood stasis and influence on myocardial energy metabolism
LI Jialing WEI Jiaming LI Yuying TANG Yun LI Ya GUO Zhihua
The First Clinical College of Traditional Chinese Medicine, Hu’nan University of Chinese Medicine, Hu’nan Province, Changsha 410208, China
Abstract：Objective To investigate the clinical effect of Xingtongtai Granules in the treatment of stable angina pectoris with syndrome of qi stagnation and blood stasis and influence on myocardial energy metabolism of patients. Methods A total of 60 patients with stable angina pectoris with syndrome of qi stagnation and blood stasis treated in the outpatient department and inpatient department of the First Hospital Hu’nan University of Chinese Medicine and the Second Affiliated Hospital of Hu’nan University of Chinese Medicine from June 2018 to June 2020 were selected and they were divided into observation group and control group according to random number table method, with 30 patients in each group. The observation group was treated with Xintongtai Granules combined with Western medicine standard treatment, while the control group was treated with Trimetazidine Hydrochloride combined with Western medicine standard treatment. After four weeks of treatment, the clinical efficacy of the two groups was evaluated, and myocardial energy expenditure level and serum free fatty acids content were detected before and after treatment. Results The total effective rate of angina pectoris and electrocardiogram in the observation group was higher than that in the control group, and the differences were statistically significant (all P ＜ 0.05). The stopping rate of observation group was higher than control group, and the difference was statistically significant (P ＜ 0.05). After treatment, myocardial energy expenditure level and serum free fatty acids content in both groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (all P ＜ 0.05). Conclusion Xintongtai Granules combined with Western medicine standard treatment has a significant clinical effect in the treatment of stable angina pectoris with syndrome of qi stagnation and blood stasis, the mechanism of which may be related to the decrease of myocardial energy expenditure level and serum free fatty acids content.
李佳玲 魏佳明 李玉莹 唐云 李雅 郭志华. 心痛泰颗粒治疗气滞血瘀证稳定型心绞痛的效果及对心肌能量代谢的影响[J]. 中国医药导报, 2021, 18(11): 62-65.
LI Jialing WEI Jiaming LI Yuying TANG Yun LI Ya GUO Zhihua. Effect of Xintongtai Granules in treatment of stable angina pectoris with syndrome of qi stagnation and blood stasis and influence on myocardial energy metabolism. 中国医药导报, 2021, 18(11): 62-65.
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