Abstract：Objective To explore the effect of endoscopic ultrasound minimally invasive treatment for upper gastrointestinal submucosal tumors. Methods A total of 174 cases with upper gastrointestinal submucosal tumors in the First Affiliated Hospital of Hebei North University from September 2017 to September 2019 were selected as research objects. All patients underwent endoscopic mucosal dissection. The nature, origin and distribution of upper gastrointestinal submucosal tumors were observed. The diagnostic coincidence rate of digestive endoscopy was observed, pathological diagnosis as the “gold standard”. The levels of serum tumor markers including carbohydrate antigen (CA)15-3, carcinoembryonic antigen (CEA), CA19-9 and tumour-specific growth factor were compared before and after treatment. The incidence of complications was recorded. Results Esophageal leiomyoma is the most common esophageal lesion, mainly distributed in the lower thoracic segment and upper thoracic segment, mostly originated from the muscular mucosa, and the echo characteristic is hypoecho. The diagnostic coincidence rate of endoscopic ultrasound was 99.42%. The levels of CA15-3, CEA, CA19-9 and tumor-specific growth factor after treatment were lower than those before treatment, with statistical significance (all P < 0.05). After minimally invasive treatment, nine patients developed obvious epigastric pain or retrosternal pain 24 h after surgery, three patients developed perforation, and seven patients developed significant postoperative bleeding. All patients were improved after targeted treatment. Conclusion Endoscopic ultrasound minimally invasive treatment for upper gastrointestinal submucosal tumors can not only help the clinical diagnosis of patients, but also provide corresponding treatment, with few complications and high safety, which is worthy of application and promotion.
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