Abstract：Objective To explore the effect of low-calcium dialysis combined with high-flux dialysis (HFHD) on uremia maintenance hemodialysis and its effect on calcium and phosphorus metabolism, so as to provide a basis for patient diagnosis and treatment. Methods The diagnosis and treatment of 81 patients with uremia maintenance hemodialysis who were admitted to Department of Nephrology, Ma’anshan People’s Hospital of Anhui Province from March 2017 to January 2020 were retrospectively analyzed. According to different treatment methods, they were divided into observation group (41 cases) and control group (40 cases). The control group was treated with normal calcium dialysis combined with HFHD, and the observation group was treated with low calcium dialysis combined with HFHD. After six months of treatment, serum calcium, phosphorus, parathyroid hormone (iPTH), renal function (serum creatinine [SCR], urea nitrogen [BUN] ), β2-microglobulin (β2-MG), C-reactive protein (CRP) levels and complications were compared. Results Compared with before treatment, after treatment, blood calcium, blood phosphorus and calcium phosphorus product in the two groups were significantly decreased, and observation group was significantly lower than control group (P ＜ 0.05); compared with before treatment, after treatment, SCR, BUN, β2-MG and iPTH levels in the two groups were significantly decreased (P ＜ 0.05), but there was no statistical significance between the two groups (P ＞ 0.05). After treatment, CRP levels in both groups were significantly decreased, and observation group was lower than control group (P ＜ 0.05); there was no significant difference in complications between the two groups (P ＞ 0.05). Conclusion Low calcium dialysis combined with HFHD in uremic maintenance hemodialysis has good effect, can significantly correct the disorder of serum calcium and phosphorus metabolism, improve renal function, reduce the body inflammatory reaction, with high safety, and can be widely used in clinic.
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