Cynergy脉冲染料激光联合倍他米松、5-氟尿嘧啶局部封闭治疗瘢痕疙瘩的效果

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摘要目的观察Cynergy脉冲染料激光联合倍他米松、5-氟尿嘧啶（5-Fu）局部封闭治疗瘢痕疙瘩的效果。方法选取2018年1月—2019年10月石家庄市人民医院皮肤科收治的120例瘢痕疙瘩患者作为研究对象，根据随机数字表法将其分为三组，每组40例。对照组A采用Cynergy脉冲染料激光治疗；对照组B采用倍他米松、5-Fu局部封闭治疗；试验组采用Cynergy脉冲染料激光治疗联合倍他米松、5-Fu局部封闭治疗。三组均每4周治疗1次，共4次。比较治疗前后温哥华瘢痕评定量表评分和瘢痕面积变化，临床疗效，不良反应发生情况和复发率。结果治疗后三组色泽、血管分布、厚度、柔软度、瘙痒程度评分均较治疗前下降，且试验组均低于对照组A、B，治疗后三组瘢痕面积均较治疗前缩小，且试验组小于对照组A、B，差异均有统计学意义（均P ＜ 0.05）；试验组与对照组A、试验组与对照组B临床疗效分布比较，差异均有统计学意义（均P ＜ 0.05）；试验组与对照组A和对照组B不良反应发生率比较，差异均无统计学意义（均P ＞ 0.05）；试验组复发率低于对照组A、B，差异均有统计学意义（均P ＜ 0.05）。结论 Cynergy脉冲染料激光与倍他米松、5-Fu局部封闭治疗瘢痕疙瘩均可减轻症状，缩小瘢痕面积，且二者联合作用更佳，效果更理想，安全可靠，还可降低复发率。

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	卢会秀曹海育李建英孙静梁云川

关键词 ： Cynergy脉冲染料激光, 倍他米松, 5-氟尿嘧啶, 封闭治疗, 瘢痕疙瘩

Abstract：Objective To observe the effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil (5-Fu) partial closure in the treatment of keloids. Methods A total of 120 patients with keloids treated in the Department of Dermatology, Shijiazhuang People’s Hospital from January 2018 to October 2019 were selected as the research subjects, and they were divided into three groups according to random number table method, with 40 patients in each group. Control group A was treated with Cynergy pulsed dye laser. Control group B was treated with Betamethasone and 5-Fu partial closure treatment. Experimental group was treated with Cynergy pulsed dye laser therapy combined with Betamethasone and 5-Fu partial closure treatment. All the three groups were treated once every four weeks for four times in total. The Vancouver scar rating scale score and changes in scar area before and after treatment, clinical efficacy, incidence of adverse reactions and recurrence rate were compared. Results After treatment, the color, vascular distribution, thickness, softness and pruritus scores in the three groups were all decreased compared with before treatment, and the experimental group was all lower than the control group A and B. After treatment, the scar area in the three groups was smaller than before treatment, and the experimental group was smaller than the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Comparison of clinical efficacy distribution between the experimental group and the control group A and between the experimental group and the control group B showed statistically significant differences (all P ＜ 0.05). There was no statistical significance in the rate of adverse reactions between the experimental group and the control group A, and between the experimental group and the control group B (all P ＞ 0.05). The recurrence rate of the experimental group was lower than that of the control group A and B, and the differences were statistically significant (all P ＜ 0.05). Conclusion Cynergy pulsed dye laser combined with Betamethasone and 5-Fu partial closure for keloids treatment can both reduce symptoms and reduce scar area, and the combination of the two is more effective, the effect is more ideal, safe and reliable, and can reduce recurrence rate.

Key words： Cynergy pulsed dye laser Betamethasone 5-Fluorouracil Partial closure Keloids

基金资助:河北省医学科学研究课题计划项目（20191464）。

引用本文:

卢会秀曹海育李建英孙静梁云川. Cynergy脉冲染料激光联合倍他米松、5-氟尿嘧啶局部封闭治疗瘢痕疙瘩的效果[J]. 中国医药导报, 2021, 18(10): 84-87.
LU Huixiu CAO Haiyu LI Jianying SUN Jing LIANG Yunchuan. Effect of Cynergy pulsed dye laser combined with Betamethasone and 5-Fluorouracil partial closure in the treatment of keloids. 中国医药导报, 2021, 18(10): 84-87.

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