线粒体自噬在脓毒症中的研究进展

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摘要脓毒症是重症监护病房的常见疾病，具有高发病率、高死亡率的特点，易发生全身多器官损伤甚至衰竭。当前，脓毒症的治疗以病因治疗、液体复苏、抗感染等目标为主，由于病情进展迅速导致治疗效果欠佳。线粒体自噬可通过Parkin依赖性途径和Parkin非依赖性途径清除受损、老化和功能障碍的线粒体，有效避免细胞过度损伤，维持细胞内环境稳态，在许多疾病中发挥重要作用。线粒体自噬在Parkin、Fun14结构相关蛋白1、Bcl-2相互作用蛋白3、线粒体动力学相关蛋白1介导下能够抑制炎症因子和活性氧的释放，减少多器官功能障碍的发生，其在脓毒症中发挥保护作用。本文对线粒体自噬在脓毒症中的作用机制和治疗方面进行综述，旨在为脓毒症的治疗提供新的依据。

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	张欣桐1 刘景卓1 李盼1 马德胜1 马莉2

关键词 ：线粒体自噬, 脓毒症, Parkin, 多器官功能障碍, 治疗

Abstract：Sepsis is a common disease in intensive care unit, which is characterized by high morbidity and mortality, and is easy to cause systemic multiple organ damage and even failure. At present, the treatment of sepsis mainly focuses on etiological treatment, fluid resuscitation, anti-infection and other targets, but the treatment effect is not good due to the rapid progress of the disease. Mitophagy can clear damaged, aged and dysfunctional mitochondria through Parkin-dependent and Parkin-independent pathways, effectively avoid excessive cell damage and maintain homeostasis of intracellular environment, which plays an important role in many diseases. Mitophagy, mediated by Parkin, Fun14 domain-containing protein 1, Bcl-2 interacting protein 3, dynamin related protein 1, can inhibit the release of inflammatory factors and reactive oxygen species, reduce the occurrence of multiple organ dysfunction, and play a protective role in sepsis. This article reviews the aspects of the mechanism and treatment of mitophagy in sepsis, so as to provide a new basis for the treatment of sepsis.

Key words： Mitophagy Sepsis Parkin Multiple organ dysfunction Therapy

基金资助:国家临床重点专科建设项目（甘财社〔2014〕20号）。

通讯作者: 马莉（1970-），女，博士，硕士生导师，主任医师，兰州大学第二医院重症医学科三病区主任；研究方向：脓毒症的基础和临床研究。

作者简介: 张欣桐（1994-），女，兰州大学第二临床医学院2018级急诊医学专业在读硕士研究生；研究方向：脓毒症等急危重症。

引用本文:

张欣桐1 刘景卓1 李盼1 马德胜1 马莉2. 线粒体自噬在脓毒症中的研究进展[J]. 中国医药导报, 2021, 18(10): 39-42.
ZHANG Xintong1 LIU Jingzhuo1 LI Pan1 MA Desheng1 MA Li2. Research progress of mitophagy in sepsis. 中国医药导报, 2021, 18(10): 39-42.

链接本文:

https://www.yiyaodaobao.com.cn/CN/ 或 https://www.yiyaodaobao.com.cn/CN/Y2021/V18/I10/39

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