Research progress on molecular mechanisms of autophagy and apoptosis in endometriosis
CONG Huifang1 LI Yang2 YU Yang1 ZHANG Tianchan1,3
1.Department of Gynecology, the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150001 China; 2.the Second Clinical Medical College of Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin, 150001 China;
3.Department of Traditional Chinese Medicine, Heilongjiang Academy of Chinese Medicine Sciences, Heilongjiang Province, Harbin 150036, China
Abstract：Endometriosis is an estrogen-dependent progressive disease, the occurrence and development of the disease are mostly related to the autophagy and apoptosis mechanisms of endometrial cells. Patients with endometriosis promote the occurrence of endometriosis by inhibiting the level of apoptosis of endometriosis cells to protect cells and promote cell proliferation. However, the role of autophagy in endometriosis is still controversial. However, whether autophagy is an “enemy” or a “friend” in endometriosis is still controversial. Both low and high levels of autophagy have been observed in endometriosis lesions, and can promote the development of endometriosis via inhibiting apoptosis in different ways. Therefore, the relationship between autophagy and apoptosis in endometriosis and the expression level of autophagy still need to be explored continuously.
[1] Peiris AN，Chaljub E，Medlock D. Endometriosis[J]. J Am Med Assoc，2018，320（24）：1244-1256.
[2] 金楚瑶，李楠，李智文，等.月经初潮年龄提前的危险因素及其健康影响的研究进展[J].中国生育健康杂志，2018， 29（4）：386-388.
[3] Falcone T，Flyckt R. Clinical Management of Endometriosis [J]. Obstet Gynecol，2018，131（3）：557-571.
[4] 丛珊珊，张广美.子宫内膜异位症药物治疗新进展[J].中国生育健康杂志，2020，31（3）：292-295.
[5] Bulun SE，Yilmaz BD，Sison C，et al. Endometriosis [J]. Endocr Rev，2019，40（4）：1048-1079.
[6] Xu H，Gao Y，Shu Y，et al. EPHA3 enhances macrophage autophagy and apoptosis by disrupting the mTOR signaling pathway in mice with endometriosis[J]. Bioscience Rep，2019，39（7）：BSR20182274.
[7] D’Arcy MS. Cell death：a review of the major forms of apoptosis，necrosis and autophagy[J]. Cell Biol Int，2019， 43（6）：582-592.
[8] Varshney P，Saini N. PI3K/AKT/mTOR activation and autophagy inhibition plays a key role in increased cholesterol during IL-17A mediated inflammatory response in psoriasis [J]. BBA-Mol Basis Dis，2018，1864（5）：1795-1803.
[9] Wang Y，Zhang H. Regulation of Autophagy by mTOR Signaling Pathway [M]. Adv Exp Med Biol，2019，12（6）：67-83.
[10] He Y，She H，Zhang T，et al. p38 MAPK inhibits autophagy and promotes microglial inflammatory responses by phosphorylating ULK1[J]. J Cell Biol，2018，217（1）：315-328.
[11] Bryant KL，Stalnecker CA，Zeitouni D，et al. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer[J]. Nat Med，2019，25（4）：628-640.
[12] Denisenko TV，Pivnyuk AD，Zhivotovsky B. p53-Autophagy-Metastasis Link [J]. Cancers，2018，10（5）：148.
[13] Yin Y，Sun G，Li E，et al. ER stress and impaired autophagy flux in neuronal degeneration and brain injury [J]. Ageing Res Rev，2017，34：3-14.
[14] Li M，Lu M，Liu M，et al. An observation of the role of autophagy in patients with endometriosis of different stages during secretory phase and proliferative phase [J]. Curr Gene Ther，2018，18（5）：286-295.
[15] Mei J，Zhu X，Jin L，et al. Estrogen promotes the survival of human secretory phase endometrial stromal cells via CXCL12CXCR4 up-regulation-mediated autophagy inhibition [J]. Hum Reprod，2015，30（7）：1677-1689.
[16] Zhan L，Yao S，Sun S，et al. NLRC5 and autophagy combined as possible predictors in patients with endometriosis [J]. Fertil Steril，2018，110（5）：949-956.
[17] Liu H，Zhang Z，Xiong W，et al. Hypoxia-inducible factor-1α promotes cells migration and invasion by upregulating autophagy in endometriosis [J]. Reproduction，2017， 153（6）：809-820.
[18] Liu H，Zhang Z，Xiong W，et al. Long non-coding RNA MALAT1 mediates hypoxia-induced pro-survival autophagy of endometrial stromal cells in endometriosis [J]. J Cell Mol Med，2019，23（1）：439-452.
[19] Ruiz A，Rockfield S，Taran N，et al. Effect of hydroxychloroquine and characterization of autophagy in a mouse model of endometriosis[J]. Cell Death Dis，2016，7（1）：e2059.
[20] Hopwood D，Levison DA. Atrophy and apoptosis in the cyclical human endometrium[J]. J Pathol，1976，119（3）：159-166.
[21] 郎景和.对子宫内膜异位症认识的历史，现状与发展[J].中国实用妇科与产科杂志，2020，36（3）：193-196.
[22] Samimi M，Pourhanifeh MH，Mehdizadehkashi A，et al. The role of inflammation，oxidative stress，angiogenesis，and apoptosis in the pathophysiology of endometriosis：Basic science and new insights based on gene expression [J]. J Cell Physiol，2019，234（11）：19384-19392.
[23] 张瑜，唐虹.紫草素对子宫内膜异位症大鼠内膜细胞凋亡影响实验研究[J].辽宁中医药大学学报，2018，20（9）：50-53.
[24] 肖新春，任郭英.桂枝茯苓对子宫内膜异位症大鼠异位内膜组织生存素和半胱氨酸蛋白-3表达的影响[J].中国临床药理学杂志，2018，34（3）：291-293.
[25] Jiang R，Yang Y，Huang Q，et al. Immunohistochemical expression of estrogen receptor α，Bcl-2 and NF-κB P65 in the polyps of patients with and without endometriosis [J]. J Obstet Gynaecol Re，2020，46（9）：1819-1826.
[26] Kang R，Zeh HJ，Lotze MT，et al. The Beclin 1 network regulates autophagy and apoptosis[J]. Cell Death Differ，2011，18（4）：571-580.
[27] Houston JP. Apoptosis and autophagy[J]. Cytom Part A，2019，95（6）：655-656.
[28] Song S，Tan J，Miao Y，et al. Crosstalk of autophagy and apoptosis：Involvement of the dual role of autophagy under ER stress [J]. J Cell Physiol，2017，232（11）：2977-2984.
[29] Arisa T，Kaori K，Erina S，et al. Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway[J]. J Clin Endocr Metab，2019，104（11）：5547-5554.
[30] Fabio B，Lorenzo FD，Simone F. Inhibition of PI3KAKTmTOR pathway for the treatment of endometriosis[J]. Brit J Pharmacol，2018，175（17）：3626-3627.
[31] Choi J，Jo M，Lee E，et al. Differential induction of autophagy by mTOR is associated with abnormal apoptosis in ovarian endometriotic cysts[J]. Mol Hum Reprod，2014，20（4）：309-317.
[32] Borahay MA，Lu F，Ozpolat B，et al. Mullerian inhibiting substance suppresses proliferation and induces apoptosis and autophagy in endometriosis cells in vitro[J]. ISRN Obstet Gynecol，2013，2013：1-6.
[33] Allavena G，Carrarelli P，Del Bello B，et al. Autophagy is upregulated in ovarian endometriosis：a possible interplay with p53 and heme oxygenase-1[J]. Fertil Steril，2015， 103（5）：1244-1251.
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