Optimization of extraction process of Astragalus and Radix Notoginseng by multi index comprehensive score method
LAN Yang1 ZHANG Shijin1 WANG Yali1 GUO Tingdong1 TANG Zhili1 XIE Xisheng2
1.Nanchong Key Laboratory of Individualized Drug Therapy, Department of Pharmacy, the Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Sichuan Province, Nanchong 637000, China;
2.Department of Nephrology, the Second Clinical Medical College of North Sichuan Medical College Nanchong Central Hospital, Sichuan Province, Nanchong 637000, China
Abstract：Objective To optimize the extraction process of Astragalus and Radix Notoginseng by multi index comprehensive score method combined with orthogonal design. Methods The contents of isoflavone glucoside, ferulic acid, ginsenoside Rg1 in the prescription and the comprehensive score of extract yield were used as evaluation indexes. The effects of water multiple, extraction time and extraction times on the comprehensive score were investigated by orthogonal test. Results The optimal extraction process was to add ten times of water, extract four times, 30 min each time. Under these conditions, the average content of isoflavone glucoside, ferulic acid, ginsenoside Rg1 were 0.61, 1.51, 26.23 mg/g respectively, and the and extract yield was 41.02%, and the RSD was 0.94%, 1.38%, 1.20%, 0.71%, respectively (n = 3). Conclusion The optimized process is stable and feasible, which can be used as the extraction process of this preparation.
兰杨1 张仕瑾1 王娅俐1 郭廷东1 唐志立1 谢席胜2. 多指标综合评分法优选黄芪三七合剂提取工艺[J]. 中国医药导报, 2021, 18(10): 23-25,30.
LAN Yang1 ZHANG Shijin1 WANG Yali1 GUO Tingdong1 TANG Zhili1 XIE Xisheng2. Optimization of extraction process of Astragalus and Radix Notoginseng by multi index comprehensive score method. 中国医药导报, 2021, 18(10): 23-25,30.
京公网安备 11010502046598号