Effect of Compound Chaijin Jieyu Tablets in the treatment of depression and its influence on serum inflammatory factors and neurotransmitters
ZHUO Dan1 WANG Yuhong1,2 YU Jingbo1,2 ZHAO Hongqing3 LI Zirong1 YAN Xiaoyuan2,3 HE Haixia3 YAO Xinyan3
1.Hu’nan University of Chinese Medicine, Hu’nan Province, Changsha 410208, China;
2.the National Key Laboratory Breeding Base of Hu’nan Province Traditional Chinese Medicine Powder and Innovative Medicine Ministry, Hu’nan Province, Changsha 410208, China;
3.the First Affiliated Hospital of Hu’nan University of Chinese Medicine, Hu’nan Province, Changsha 410007, China
Abstract：Objective To explore the effect of Compound Chaijin Jieyu Tablets in treating depression and its influence on serum inflammatory factors and monoamine neurotransmitters. Methods A total of 80 patients with depression admitted to the Department of Neurology, the First Affiliated Hospital of Hu’nan University of Chinese Medicine from May 2018 to December 2019 were selected. All observed cases were divided into observation group and control group according to the random number table method, with 40 cases in each group. The course of treatment was eight weeks. The observation group was treated with self-prepared Compound Chaijin Jieyu Tablets, and the control group was treated with Western medicine Hydrochloride Sertraline Tablets. The clinical efficacy and traditional Chinese medicine (TCM) syndromes efficacy were compared between the two groups after four and eight weeks of treatment. The levels of serum monoamine neurotransmitters (5-hydroxytryptamine, norepinephrine, dopamine) and inflammatory factors (tumor necrosis factor-α, interleukin-6, interleukin-2) were compared between the two groups after eight weeks of treatment. The safety of the two groups was observed. Results During the treatment, two patients in the control group and three patients in the observation group fell off. After four weeks of treatment, there was no significant difference in clinical efficacy and TCM syndrome efficacy between the two groups (P ＞ 0.05). After eight weeks of treatment, there was no statistically significant difference in clinical efficacy between the two groups (P ＞ 0.05), but the total effective rate of TCM syndromes in the observation group was higher than that in the control group, with statistically significant difference (P ＜ 0.05). After eight weeks of treatment, the levels of monoamine neurotransmitters were higher than those before the treatment, and the levels of inflammatory factors were lower than those before the treatment, with statistical significant differences (all P ＜ 0.05). But there was no statistical significance in serum levels of inflammatory factors and neurotransmitters between groups (P ＞ 0.05). The patients’ liver and kidney function, myocardial enzymes, three routine tests, and electrocardiogram examination before and after treatment were not found any obvious abnormal changes. Conclusion The Compound Chaijin Jieyu Tablet has a positive effect on the treatment of depression with liver depression and spleen deficiency, and has high safety, which is suitable for clinical application.
卓丹1 王宇红1,2 于静波1,2 赵洪庆2 李姿蓉1 蔺晓源2,3 贺海霞3 姚欣艳3. 复方柴金解郁片治疗抑郁症的效果及对血清炎症因子和神经递质的影响[J]. 中国医药导报, 2021, 18(8): 114-117,129.
ZHUO Dan1 WANG Yuhong1,2 YU Jingbo1,2 ZHAO Hongqing3 LI Zirong1 YAN Xiaoyuan2,3 HE Haixia3 YAO Xinyan3. Effect of Compound Chaijin Jieyu Tablets in the treatment of depression and its influence on serum inflammatory factors and neurotransmitters. 中国医药导报, 2021, 18(8): 114-117,129.
2021, Vol. 18 
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