阿立哌唑对抑郁症患者的疗效及相关因子水平的影响

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摘要目的探讨阿立哌唑治疗抑郁症的效果及对相关因子的影响作用。方法选取2015年7月—2019年3月河北省石家庄市第八医院确诊的300例抑郁症患者，按照随机数字表法将其分为研究组和对照组，每组各150例。所有患者均经过选择性5-羟色胺再摄取抑制剂（SSRI）治疗后效果不佳，研究组采用文法拉辛+阿立哌唑治疗，对照组采用文法拉辛+安慰剂治疗。两组疗程为12周。结果整体分析发现：两组汉密尔顿抑郁量表（HAMD-21）评分组间比较、时间点比较及交互作用差异均有统计学意义（均P ＜ 0.05）。组内比较：两组HAMD-21评分各时间点比较，差异均有统计学意义（均P ＜ 0.05）；组间比较：在治疗4、8、12周后，研究组HAMD-21评分均低于对照组，差异均有统计学意义（均P ＜ 0.05）。治疗12周后，两组血清5-羟色胺、去甲肾上腺素和多巴胺水平均较治疗前升高，且研究组高于对照组，差异均有统计学意义（均P ＜ 0.05）。治疗12周后，研究组整体临床疗效分布情况优于对照组，差异有统计学意义（P ＜ 0.05）。在治疗过程中，两组头痛、恶心、失眠、出汗、体重增加发生率比较，差异无统计学意义（P ＞ 0.05）。结论文法拉辛+阿立哌唑治疗抑郁症的效果优于单用文法拉辛，其作用机制可能与更好的调节相关神经递质有关。

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	张亚莉郑鸿伟李伟彩

关键词 ：阿立哌唑, 抑郁症, 文法拉辛, 5-羟色胺, 多巴胺, 去甲肾上腺素

Abstract：Objective To investigate the effect of Aripiprazole in the treatment of depression and its effect on related factors. Methods A total of 300 patients with depression diagnosed in the Eighth Hospital of Shijiazhuang City, Hebei Province from July 2015 to March 2019 were selected and divided into study group and control group according to random number table method, with 150 patients in each group. All patients did not respond well to selective serotonin reuptake inhibitors (SSRIs). The study group was treated with Venfarazine + Aripiprazole, while the control group was treated with Venfarazine + placebo. The two groups were treated for twelve weeks. Results Overall analysis showed that there were significant differences in the Hamilton depression scale (HAMD-21) between the two groups in comparison between groups, time point comparison and interaction (all P ＜ 0.05). Comparison within the two groups: HAMD-21 scores of the two groups were compared at each time point, and the differences were statistically significant (all P ＜ 0.05). Comparison between groups: After four, eight and twelve weeks of treatment, the HAMD-21 scores in the study group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). After twelve weeks of treatment, serum levels of 5-hydroxytryptamine, norepinephrine and dopamine in both groups were higher than before treatment, and those in the study group were higher than those in the control group, and the differences were statistically significant (all P < 0.05). After twelve weeks of treatment, the overall distribution of clinical efficacy in the study group was better than that in the control group, and the difference was statistically significant (P ＜ 0.05). During the treatment, there was no significant difference in the incidence of headache, nausea, insomnia, sweating and weight gain between the two groups (P > 0.05). Conclusion The effect of Venfarazine + Aripiprazole in the treatment of depression is better than Venfarazine alone, and its mechanism of action may be related to better regulation of related neurotransmitters.

Key words： Aripiprazole Depression Venfarazine 5-hydroxytryptamine Dopamine Norepinephrine

基金资助:河北省卫生和计划生育委员会医学科学研究重点课题（ZD20140462）。

引用本文:

张亚莉郑鸿伟李伟彩. 阿立哌唑对抑郁症患者的疗效及相关因子水平的影响[J]. 中国医药导报, 2021, 18(7): 104-107.
ZHANG Yali ZHENG Hongwei LI Weicai. Effects of Aripiprazole on the efficacy and related factors in patients with depression. 中国医药导报, 2021, 18(7): 104-107.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2021/V18/I7/104

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