衣康酸在炎症疾病诊治中的研究进展

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摘要衣康酸在人体内主要由巨噬细胞生成，是一种具有抗炎、抗菌等广泛临床应用潜力的物质。衣康酸在炎症、免疫疾病中起着重要作用，衣康酸的抗炎、抗菌机制涉及巨噬细胞的活化、极化、活性氧的生成、代谢重编程、免疫调节、Irg1通路、IκBζ炎症通路等，引起了科学家的广泛关注。研究发现，阻断或增加衣康酸的生成可以促进或抑制疾病的发生与发展，但其在炎症、抗菌的机制尚不完全明确。因此，深入研究衣康酸在疾病中扮演的角色期望为衣康酸在临床疾病中的应用提供参考。

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	唐俊鹏魏娟英李润琪邹伟

关键词 ：衣康酸, 生物标志物, 抗菌, 炎症, 免疫调节

Abstract：Itaconic acid is mainly produced by macrophages in the human body, and it is a substance with extensive clinical application potential such as anti-inflammatory and antibacterial. Itaconic acid plays an important role in inflammation and immune diseases. The anti-inflammatory and antibacterial mechanisms of itaconic acid involve macrophage activation, polarization, generation of reactive oxygen species, metabolic reprogramming, immune regulation, Irg1 pathway, IκBζ inflammation parhrray etc. It has attracted widespread attention from scientists. Studies have found that blocking or increasing the production of itaconic acid can promote or inhibit the occurrence and development of diseases, but its mechanism in inflammation and antibacterial is not completely clear. Therefore, in-depth study of the role of itaconic acid in diseases is expected to provide reference for the application of itaconic acid in clinical drsease.

Key words： Itaconic acid Biomarker Antibacterial Inflammation Immunomodulatory

基金资助:湖南省卫计委重点研究计划项目（A2017020）；
湖南省自然科学基金科卫联合项目（2019JJ80057）。

通讯作者: 邹伟（1964.12-），男，主任医师，硕士生导师；研究方向：神经退行性疾病

作者简介: 唐俊鹏（1995.2-），男，南华大学南华学院2018级神经内科专业在读硕士研究生；研究方向：神经退行性疾病。

引用本文:

唐俊鹏魏娟英李润琪邹伟. 衣康酸在炎症疾病诊治中的研究进展[J]. 中国医药导报, 2021, 18(7): 51-54.
TANG Junpeng WEI Juanying LI Runqi ZOU Wei. Research progress of itaconic acid in the diagnosis and treatment of inflammatory diseases. 中国医药导报, 2021, 18(7): 51-54.

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http://www.yiyaodaobao.com.cn/CN/ 或 http://www.yiyaodaobao.com.cn/CN/Y2021/V18/I7/51

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