Therapeutic effect of Sitagliptin Phosphate combined with Metformin on blood glucose control and insulin resistance in patients with type 2 diabetes mellitus
YUAN Ting
Department of Endocrinology, Fuyang Women’s and Children’s Hospital, Anhui Province, Fuyang 236000, China
Abstract：Objective To investigate the effect of Sitagliptin Phosphate combined with Metformin on the improvement of blood glucose control and insulin resistance in patients with type 2 diabetes mellitus, and to provide evidence for the diagnosis and treatment of patients. Methods Eighty patients with type 2 diabetes mellitus who were admitted to Fuyang Women’s and Children’s Hospital, Anhui Province from April 2019 to April 2020 were selected as the research subjects. They were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was treated with Metformin and the observation group was treated with Sitagliptin Phosphate combined with Metformin. Both groups were treated for 12 weeks. The effects of treatment were compared between the two groups. The changes of fasting blood glucose (FBG), 2 h postprandial blood glucose (2hPBG), glycosylated hemoglobin (HbA1c) and fasting insulin (FINS) before and after treatment were recorded in the two groups, and the adverse reactions during treatment in the two groups were counted. Results The total effective rate of observation group was significantly higher than that of control group, the difference was statistically significant (P ＜ 0.05). After treatment, FBG, 2hPBG and HbA1c in the observation group were lower than those in the control group, with statistical significance (all P ＜ 0.05). FINS in observation group was higher than that in control group, and the difference was statistically significant (P ＜ 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Sitagliptin Phosphate combined with Metformin has a definite effect on the treatment of type 2 diabetes mellitus, which can effectively improve blood glucose, improve the secretion function of pancreatic β cells, reduce insulin resistance, and has a high safety.
员婷. 磷酸西格列汀联合二甲双胍对2型糖尿病患者血糖控制及胰岛素抵抗的治疗效果[J]. 中国医药导报, 2021, 18(6): 91-94.
YUAN Ting. Therapeutic effect of Sitagliptin Phosphate combined with Metformin on blood glucose control and insulin resistance in patients with type 2 diabetes mellitus. 中国医药导报, 2021, 18(6): 91-94.
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2021, Vol. 18 
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