Analysis on the medication rules of traditional Chinese medicine in treating poststroke depression based on traditional Chinese medicine inheritance support system
YUAN Minjiao1 YUAN Jie2 HAN Zucheng2
1.The First Clinical Medical College, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712000, China;
2.Department of Encephalopathy, Shaanxi Hospital of Traditional Chinese Medicine, Shaanxi Province, Xi’an 710000, China
Abstract：Objective To explore the medication rules of traditional Chinese medicine in treating poststroke depression by “traditional Chinese medicine inheritance support system (V2.5)”. Methods The literatures related to the treatment of poststroke depression with traditional Chinese medicine in CNKI, CBM, VIP and Wanfang Data were collected, the time limit for retrieval was from inception to February 2020. The effective prescriptions after screening were entered into the traditional Chinese medicine inheritance support system, to establish a prescription database for treating poststroke depression. Data mining methods such as association rules, complex system entropy clustering and unsupervised entropy hierarchical clustering were used to analyze the data. Results A total of 269 effective prescriptions were included, involving 177 kinds of Chinese medicine. The main nature of drugs were warm, cold and calm, and the main flavors were bitter and pungent, followed by the sweet. The main drugs were belonged to liver, heart and spleen channels. Eighteen kinds of Chinese medicine with a frequency more than 57. The top five Chinese medicines were Radix Bupleuri, Radix Curcumae, Rhizoma Ligustici Chuanxiong, Radix Angelicae Sinensis and Radix Paeoniae Alba. The top five core drug combinations were Rhizoma Ligustici Chuanxiong - Radix Bupleuri, Radix Curcumae - Radix Bupleuri, Radix Angelicae Sinensis - Radix Bupleuri, Radix Paeoniae Alba - Radix Bupleuri, Radix Bupleuri - Poria. Fourteen core drug combinations and seven new prescriptions were obtained through complex system entropy clustering. Conclusion In the treatment of poststroke depression, traditional Chinese medicine for dispersing the stagnated liver-energy and invigorating the spleen is often used, which is often combined with the products for regulating vital energy, nourishing the heart and calming the nerves.
袁敏皎1 袁捷2 韩祖成2. 基于中医传承辅助平台挖掘中医药治疗卒中后抑郁的用药规律[J]. 中国医药导报, 2021, 18(5): 159-162.
YUAN Minjiao1 YUAN Jie2 HAN Zucheng2. Analysis on the medication rules of traditional Chinese medicine in treating poststroke depression based on traditional Chinese medicine inheritance support system. 中国医药导报, 2021, 18(5): 159-162.
2021, Vol. 18 
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