Relationship between TIBI classification, vascular recanalization, neurological function and short-term prognosis in patients with acute anterior circulation cerebral infarction treated with rt-PA intravenous thrombolysis
LIU Jianhuai WANG Benxiao WANG Junjun
Department of Neurology, Anhui Wanbei Coal-Electricity Group General Hospital, Anhui Province, Suzhou 234000, China
Abstract:Objective To study the relationship between TIBI classification, vascular recanalization, neurological function and short-term prognosis in patients with acute anterior circulation cerebral infarction treated with recombinant tissue-type plasminogen activator(rt-PA) intravenous thrombolysis. Methods A total of 102 patients with acute anterior circulation cerebral infarction who received intravenous thrombolysis from July 2018 to December 2019 in Anhui Wanbei Coal-Electricity Group General Hospital were selected as study objects. All patients were treated with rt-PA intravenous thrombolysis, and the patients were divided into good prognosis group (44 cases) and poor prognosis group (58 cases) according to the modified Rankin scale (mRS) score after treatment. The clinical baseline data were compared; logistic regression analysis was used for multivariate analysis, and Pearson correlation coefficient analysis was used for correlation analysis. Results Age and national institutes of health stoke scale (NIHSS) score of good prognosis group were lower than those of poor prognosis group, and the differences were statistically significant (P < 0.05). TIBI grade and total vascular recanalization rate in good prognosis group were higher than those in poor prognosis group (P < 0.05). TIBI grade, total vascular recanalization rate and NIHSS score were independent risk factors for short-term prognosis (OR >1, P < 0.05). There was a positive correlation between mRS score and NIHSS score (r = 0.278, P < 0.01), and a negative correlation between mRS score and TIBI grade and total vascular recanalization rate (r = -0.527, -0.372, P < 0.01). Conclusion The TIBI classification, vascular recanalization rate and NIHSS score of patients with acute anterior circulation cerebral infarction rt-PA intravenous thrombolysis are independent risk factors that affect the short-term prognosis of patients after treatment, and the patient’s mRS score was positively correlated with NIHSS score, but negatively correlated with TIBI grade and vascular recanalization rate.
刘建魁 王本孝 王俊珺. 急性前循环脑梗死rt-PA静脉溶栓患者TIBI分级和血管再通、神经功能及短期预后的关系[J]. 中国医药导报, 2021, 18(5): 76-79.
LIU Jianhuai WANG Benxiao WANG Junjun. Relationship between TIBI classification, vascular recanalization, neurological function and short-term prognosis in patients with acute anterior circulation cerebral infarction treated with rt-PA intravenous thrombolysis. 中国医药导报, 2021, 18(5): 76-79.