Relationship between serum UA level and intracranial / extracranial atherosclerotic stenosis in patients with cerebral infarction
YUAN Baowen1 LI Chouzhong2 CHEN Yufeng3 WEI Ling3
1.Department of Internal Medicine-Neurology, Guizhou Orthopedic Hospital, Guizhou Province, Guiyang 550000, China;
2.Department of Neurosurgery, Guizhou Provincial People’s Hospital, Guizhou Province, Guiyang 550000, China;
3.Department of Acupuncture , the First People’s Hospital of Bijie City, Guizhou Province, Bijie 551700, China
Abstract：Objective To analyze the relationship between serum uric acid (UA) level and intracranial/extracranial atherosclerotic stenosis (ICAS/EAS) in patients with cerebral infarction. Methods A total of 216 patients with cerebral infarction who were followed up in Guizhou Orthopedic Hospital from January 2019 to January 2020 were selected as the research objects. According to the presence or absence of ICAS/EAS, the patients were divided into the stenosis group (150 cases) and the control group (66 cases). The differences of serum UA level and general clinical data between the two groups were compared. The expression of serum UA levels in patients with different severity of ICAS/EAS were analyzed, and the relationship between UA level and ICAS/EAS severity were analyzed, the influencing factors of ICAS/EAS in patients with cerebral infarction was explored. Results The UA level, age, body mass index (BMI), total cholesterol (TC), low density lipoprotein (LDL) and the proportion of hypertension in the stenosis group were higher than those of the control group, while the serum high density lipoprotein (HDL) level was lower than that of the control group (all P ＜ 0.05). The UA levels of severe, moderate and mild group were higher than that of the control group, the severe, moderate group were higher than that of the mild group, and the severe group was higher than that of the moderate group (all P ＜ 0.05). Spearman correlation analysis showed that serum UA level was positively correlated with ICAS/EAS severity (rs = 0.634, P ＜ 0.001). Logistic regression analysis showed that UA (OR = 3.748), age (OR = 2.895), hypertension (OR = 3.024), TC (OR = 2.668), and LDL (OR = 2.349) were all risk factors for ICAS/EAS in patients with cerebral infarction (all P ＜ 0.05). Conclusion Serum UA level can better reflect the severity of ICAS/EAS in patients with cerebral infarction, and it is an independent risk factor of ICAS/EAS.
2021, Vol. 18 
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