Research progress on the interaction between atopic dermatitis and neuropsychiatric factors
LIN Wei1 ZHOU Qiongyan2 HUANG Jing1 ZHAO Keyu2,3 XU Suling2
1.Department of Pharmacy, the Affiliated Hospital of Medical School, Ningbo University, Zhejiang, Ningbo 315020, China;
2.Department of Dermatology, the Affiliated Hospital of Medical School, Ningbo University, Zhejiang, Ningbo 315020, China;
3.Ningbo University of Medical School, Zhejiang Province, Ningbo 315000, China
Abstract:Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczema-like rash, dry skin, and severe itching. AD can affect the mental health of patients. In severe cases, emotional abnormalities such as anxiety and depression can occur, and even suicide. Long-term mental stress or anxiety, depression and other neurological diseases may also induce or aggravate AD. This article reviews AD-related psychiatric symptoms and the influence of neuropsychiatric diseases on AD, and discusses the possible mechanisms of the interaction between the them. A vicious circle may be formed between AD and neuropsychiatric factors. Therefore, doctors should pay attention to the screening of neuropsychiatric diseases and intervene in time during the diagnosis and treatment of AD.
[1] Weidinger S,Beck LA,Bieber T,et al. Atopic dermatitis [J]. Nat Rev Dis Primers,2018,4(1):1.
[2] Wollenberg A,Barbarot S,Bieber T,et al. Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part Ⅱ [J]. J Eur Acad Dermatol,2018,32(6):850-878.
[3] Simpson EL,Bieber T,Guttman-Yassky E,et al. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis [J]. New Engl J Med,2016,375(24):2335-2348.
[4] Chang YS,Chiang BL. Sleep disorders and atopic dermatitis:A 2-way street? [J] J Allergy Clin Immun,2018,142(4):1033-1040.
[5] Jeon C,Yan D,Nakamura M,et al. Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review [J]. Dermatology Ther,2017, 7(3):349-364.
[6] Silverberg JI,Paller AS. Association between eczema and stature in 9 US population-based studies [J]. JAMA Dermatology,2015,151(4):401-409.
[7] Dalgard FJ,Gieler U,Tomas-Aragones L,et al. The psychological burden of skin diseases: a cross-sectional multicenter study among dermatological out-patients in 13 European countries [J]. J Invest Dermatol,2015,135(4):984-991.
[8] Silverberg JI,Gelfand JM,Margolis DJ,et al. Symptoms and diagnosis of anxiety and depression in atopic dermatitis in U.S. adults [J]. Brit J Dermatol,2019,181(3):554-565.
[9] Slattery MJ,Essex MJ,Paletz EM,et al. Depression,anxiety,and dermatologic quality of life in adolescents with atopic dermatitis [J]. J Allergy Clin Immun,2011,128(3):668-671.
[10] Yaghmaie P,Koudelka CW,Simpson EL. Mental health comorbidity in patients with atopic dermatitis [J]. J Allergy Clin Immun,2013,131(2):428-433.
[11] 曹春艳,周晓楠,高迎霞,等.成人特应性皮炎患者疾病感知影响因素分析[J].中国麻风皮肤病杂志,2020,36(6):366-371.
[12] Kwon JA,Park EC,Lee M,et al. Does stress increase the risk of atopic dermatitis in adolescents? results of the Korea Youth Risk Behavior Web-based Survey (KYRBWS-Ⅵ) [J]. PloS One,2013,8(8):e67890.
[13] 王莹,刘莉萍,黄建玲,等.抗抑郁药在慢性瘙痒治疗中的应用进展[J].中国皮肤性病学杂志,2017,31(10):1149-1151.
[14] Flanigan C,Sheikh A,DunnGalvin A,et al. Prenatal maternal psychosocial stress and offspring’s asthma and allergic disease:A systematic review and meta-analysis [J]. Clin Exp Allergy,2018,48(4):403-414.
[15] Chida Y,Hamer M,Steptoe A. A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis [J]. Psychosom Med,2008,70(1):102-116.
[16] Jeong KY,Kang JH. Investigation of the pruritus-induced functional activity in the rat brain using manganese-enhanced MRI [J]. J Magn Reson Imaging,2015,42(3):709-716.
[17] Soares E,Prediger RD,Nunes S,et al. Spatial memory impairments in a prediabetic rat model [J]. Neuroscience,2013,250:565-577.
[18] Yeom M,Ahn S,Oh JY,et al. Atopic dermatitis induces anxiety- and depressive-like behaviors with concomitant neuronal adaptations in brain reward circuits in mice [J]. Prog Neuropsychopharmacol Biol Psychiatry,2020,98:109818.
[19] Dowlati Y,Herrmann N,Swardfager W,et al. A meta-analysis of cytokines in major depression [J]. Biol Psychiatry,2010,67(5):446-457.
[20] Hodes GE,Pfau ML,Leboeuf M,et al. Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress [J]. Proc Nati Acad Sci USA,2014,111(45):16136-16141.
[21] Bélanger M,Allaman I,Magistretti PJ. Differential effects of pro- and anti-inflammatory cytokines alone or in combinations on the metabolic profile of astrocytes [J]. J Neurochem,2011,116(4):564-576.
[22] Kim YK,Na KS,Myint AM,et al. The role of pro-inflammatory cytokines in neuroinflammation,neurogenesis and the neuroendocrine system in major depression [J]. Prog Neuropsychopharmacol Biol Psychiatry,2016,64:277-284.
[23] Tausk F,Elenkov I,Moynihan J. Psychoneuroimmunology [J]. Dermatol Ther,2008,21(1):22-31.
[24] Peters EM,Kuhlmei A,Tobin DJ,et al. Stress exposure modulates peptidergic innervation and degranulates mast cells in murine skin [J]. Brain BehavImmun,2005,19(3):252-262.
[25] Arck P,Paus R. From the brain-skin connection:the neuroendocrine-immune misalliance of stress and itch [J]. Neuroimmunomodulation,2006,13(5/6):347-356.
[26] Paus R,Theoharides TC,Arck PC. Neuroimmunoendocrine circuitry of the ‘brain-skin connection’ [J]. Trends Immunol,2006,27(1):32-39.
[27] Maarouf M,Maarouf CL,Yosipovitch G,et al. The impact of stress on epidermal barrier function: an evidence-based review [J]. Br J Dermatol,2019,181(6):1129-1137.
[28] Elias PM,Sun R,Eder AR,et al. Treating atopic dermatitis at the source: corrective barrier repair therapy based upon new pathogenic insights [J]. J Expert Rev Dermatol,2013,8(1):7.
[29] Fukuda S,Baba S,Akasaka T. Psychological stress has the potential to cause a decline in the epidermal permeability barrier function of the horny layer [J]. Int J Cosmet Sci,2015,37(1):63-69.
[30] Misery L. Atopic dermatitis and the nervous system [J]. Clin Rev Allergy Immunol,2011,41(3):259-266.
[31] Li Y,Chen L,Du Y,et al. Fluoxetine Ameliorates Atopic Dermatitis-Like Skin Lesions in BALB/c Mice through Reducing Psychological Stress and Inflammatory Response [J]. Front Pharmacol,2016,7:318.
[32] Lee HG,Grossman SK,Valdes-Rodriguez R,et al. Topical ketamine-amitriptyline-lidocaine for chronic pruritus: A retrospective study assessing efficacy and tolerability [J]. J Am Acad Dermatol,2017,76(4):760-761.
[33] Schut C,Mollanazar NK,Kupfer J,et al. Psychological Interventions in the Treatment of Chronic Itch [J]. Acta Derm Venereol,2016,96(2):157-161.
[34] Dennis H,Rostill H,Reed J,et al. Factors promoting psychological adjustment to childhood atopic eczema [J]. J Child health Care,2006,10(2):126-139.