Effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein
JIANG Rongrong GU Jiamei
Department of Pharmacy, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, Jiangsu Province, Suzhou 215101, China
Abstract：Objective To observe the effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein, and to provide reference for clinical treatment. Methods One hundred and eighteen patients with hemiplegia after stroke admitted to Suzhou Hospital of Integrated Traditional Chinese and Western Medicine from August 2017 to August 2019 were selected. According to the treatment method, they were divided into two groups, with 59 cases in each group. The conventional group was given routine Western medicine treatment, such as active improvement circulation, regulation of brain cell metabolism, nutrition of nerve, and so on. The traditional Chinese medicine group was treated with modified Gancao Fuzi Decoction on the basis of conventional group. Both groups were treated continuously for four weeks. The changes of fibroblast growth factor 23 (FGF23), Klotho protein, highly sensitive C reactive protein (hs-CRP), interleukin-1β (IL-1β), endothelium-derived hyperpolarizing factor (EDHF), endothelin (ET), and modified Barthel index (BI) score, Fugl-Meyer assessment (FMA) score, modified Ashworth scale (MAS) were recorded before and after treatment, the total effective rate of clinical treatment in two groups was statistically analyzed. Results After treatment, the total effective rate of the traditional Chinese medicine group was higher than that of the conventional group, and the difference was statistically significant (P ＜ 0.05). The FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the two groups were lower than those before treatment (P ＜ 0.05). The EDHF level and BI score and FMA score were higher than those before treatment (P ＜ 0.05), the FGF23, Klotho protein, hs-CRP, IL-1β, ET and MAS score of the traditional Chinese medicine group were lower than those of the conventional group (P ＜ 0.05), and the EDHF level and BI score and FMA score were higher than those of the conventional group (P ＜ 0.05). Conclusion Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of hemiplegia after stroke can regulate the expression of FGF23 and Klotho protein, inhibit the inflammatory state, and improve the curative effect.
姜荣荣 顾嘉美. 甘草附子汤加减辅助西药治疗中风后偏瘫对患者炎症因子、Klotho蛋白的影响[J]. 中国医药导报, 2021, 18(3): 156-159,180.
JIANG Rongrong GU Jiamei. Effect of Western medicine assisted by modified Gancao Fuzi Decoction in the treatment of patients with hemiplegia after stroke on inflammatory factors and Klotho protein. 中国医药导报, 2021, 18(3): 156-159,180.
[1] 张瑞青，邹任玲.上肢协调功能障碍康复技术研究进展[J].生物医学工程研究，2019，38（4）：492-496.
[2] Savelov AA，Shtark MB，Mel’nikov ME，et al. Prospects of Synchronous fMRI-EEG Recording as the Basis for Neurofeedback （Exemplified on Patient with Stroke Sequelae） [J]. B Exp Biol Med，2019，166（1）：226-228.
[3] 寿雅琨，刘芳，周胜强，等.国医大师刘祖贻运用温阳活血法治疗中风后遗症经验[J].湖南中医药大学学报，2019，39（10）：1179-1182.
[4] 赵惠.经方治疗心血管疾病验案举隅[J].国际中医中药杂志，2019，41（10）：1132-1135.
[5] 王新德.各类脑血管疾病诊断要点[J].中华神经科杂志，1997，19（1）：379.
[6] 国家中医药管理局脑病急症协作组.中风病诊断与疗效评定标准（试行）[J].北京中医药大学学报，1996，5（1）：55-56.
[7] 闵瑜，吴媛媛，燕铁斌.改良Barthel指数（简体中文版）量表评定脑卒中患者日常生活活动能力的效度和信度研究[J].中华物理医学与康复杂志，2008，3（3）：185-188.
[8] Malouin F，Pichard L，Bonneau C，et al. Evaluating motor recovery early after stroke：comparison of the Fugl-Meyer Assessment and the Motor Assessment Scale [J]. Arch Phys Med Rehabil，1994，75（11）：1206-1212.
[9] 郭铁成，卫小梅，陈小红.改良Ashworth量表用于痉挛评定的信度研究[J].中国康复医学杂志，2008，23（10）：906-909.
[10] Ortiz GA ，Sacco RL. National Institutes of Health Stroke Scale （NIHSS）[M]// Wiley Encyclopedia of Clinical Trials. John Wiley & Sons，Inc，2008.
[11] 陈丛侠.多学科合作模式对急性期脑卒中患者偏瘫肢体功能恢复的影响[J].中国基层医药，2018，25（24）：3189-3192.
[12] Artur CA，Fábio MA，Linamara RB. Cutaneous temperature sensitivity alteration in subjects with chronic stroke sequelae-pharmacological perspectives [J]. J Basic Clin Physiol Pharmacol，2017，28（5）：437-441.
[13] 高晨.基于“通络补络法”的中风后遗症期治疗辨识[J].西部中医药，2019，32（8）：25-28.
[14] 赵雪梅.温阳化痰通络汤治疗阳虚痰瘀阻络型脑卒中痉挛性偏瘫[J].吉林中医药，2018，38（3）：304-306.
[15] 王晶，岳仁宋，汪晓敏，等.岳仁宋教授治疗中风后遗症的临证经验[J].浙江中医药大学学报，2018，42（6）：470-472.
[16] 杜慧萍，柳普照.化瘀涤痰汤治疗中风后遗症疗效及对患者下肢功能的影响[J].陕西中医，2018，39（8）：1087-1090.
[17] 柏久莲，汪娅蓓，马天牧，等.符为民教授从正虚痰瘀论治脑梗塞后遗症经验[J].浙江中医药大学学报，2018， 42（7）：525-528.
[18] 杨海燕，杨克勤，孙永康，等.基于数据挖掘的王新志治疗脑梗死恢复期用药规律研究[J].中国中医药信息杂志，2019，26（2）：106-109.
[19] 曾鹏廷，钟清.FGF23、klotho在慢性肾脏病患者心血管疾病中的作用[J].重庆医学，2017，46（5）：697-700.
[20] 刘启雄，邱爱霞，熊百炼.丁苯酞联合通络扶正汤治疗老年脑卒中痉挛性偏瘫患者的疗效及对Apelin-13、FGF23、Klotho水平的影响[J].中国老年学杂志，2019， 39（18）：4400-4403.
[21] 陆小青，张仟，孙熠，等.通络扶正汤治疗缺血性脑卒中临床疗效及对患者血清炎性因子和神经功能缺损程度的影响[J].四川中医，2018，6（1）：127-129.
[22] Terrill AL，Reblin M，Mackenzie JJ，et al. Development of a novel positive psychology-based intervention for couples post-stroke [J]. Rehabil Psychol，2018，63（1）：43-54.
[23] Meloux A，Brenière C，Garnier L，et al. Growth differentiation factor 15（GDF15）is a prognosis biomarker of sequelae handicap after the occurrence of an ischemic stroke [J]. Arch Cardiovasc Dis，2018，10（2）：227.
[24] Gousse G，Chabrier S，Kossorotoff M. Diagnosis and emergency treatment of stroke in children [J]. Soins Pediatr Pueric，2017，38（295）：14-16.
[25] 杨波，董辉，孙晖，等.基于尿液代谢组学的附子配伍甘草减毒作用研究[J].中国现代中药，2019，21（7）：895-902.
2021, Vol. 18 
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